About The Study: This study found that use of glucagon-like peptide-1 agonists for weight loss compared with use of bupropion-naltrexone was associated with increased risk of pancreatitis, gastroparesis, and bowel obstruction but not biliary disease. Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes.
Authors: Mahyar Etminan, Pharm.D., M.Sc., of the University of British Columbia in Vancouver, is the corresponding author.
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(doi:10.1001/jama.2023.19574)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Journal
JAMA