News Release

Perfect storm: Poor sleep quality worsens health problems in obese older people, study shows

Research conducted at the University of São Paulo involving 95 volunteers associated poor sleep quality with a deterioration in the complications caused by aging and overweight, such as anxiety, depression, body fat gain, and loss of muscle mass.

Peer-Reviewed Publication

Fundação de Amparo à Pesquisa do Estado de São Paulo

 Obese older people who sleep badly have less muscle strength and mass in their legs and arms, as well as more body fat and more symptoms of anxiety and depression than those who sleep well, according to a study conducted by researchers at the University of São Paulo (USP) in Brazil. An article on the study is published in the journal Scientific Reports.

The number of obese older people has increased worldwide in recent decades. In Brazil, the prevalence of overweight in people aged 60 and more rose from 53.7% in 2006 to 60.4% in 2019 (an increase averaging 1.16% per year), while obesity rates rose from 16.1% to 20.8% (2.34% per year), according to a study that analyzed data from the Health Ministry’s national telephone surveillance survey on risk factors for chronic diseases (Vigitel). Overweight rose most among men, and also among people of both sexes aged 80 and over. Obesity rose most among both men and women aged 70-79.

“We have a perfect storm: aging of the population and rising obesity among the elderly, many of whom frequently suffer from poor sleep quality, loss of muscle strength and mass, and mental health problems. It’s also important to bear in mind that sleep quality is a critical health factor for the general population,” said Hamilton Roschel, last author of the study described in Scientific Reports. He is a nutritionist, clinical exercise physiologist and professor at the University of São Paulo’s Medical School (FM-USP). 

The study was supported by FAPESP. The other authors of the article are Rafael Genario, Saulo GilGersiel Oliveira-Júnior, Alice Erwig Leitão, Tathiane Franco, Ruan Célio dos Santos Sales and Bruno Gualano, all of whom belong, like Roschel, to the Applied Physiology and Nutrition Research Group at the School of Physical Education and Sports (EEFE-USP); Alexandre Leopold Busse and Wilson Jacob Filho, also affiliated with FM-USP; and Eduardo Ferriolli, Professor of Geriatrics at FM-USP.

To investigate the association between sleep quality and quantitative and qualitative parameters of mental and physical health in obese older people, the researchers asked 95 obese men and women aged 65 or more to complete a sleep quality questionnaire (PSQI) and a general health questionnaire focusing on anxiety, depression and quality of life. They were divided into good sleepers (46) and bad sleepers (49) in accordance with their PSQI score. Body composition and handgrip strength were also measured. 

“We found that the poor sleepers had worse physical and mental health, with less vitality, more muscle pain, and impaired physical and mental functions. They had more body fat, less lean fat, and less muscle strength. Their anxiety, depression and quality of life scores were also worse,” Roschel said.


As the researchers note in the article, their findings serve as an alert to the importance of sleep quality to the overall health of elderly people, especially if they are obese. The presence of obesity during aging has an impact on several physiological processes, such as anabolic response and glucose metabolism, and also exacerbates the adverse effects of aging on sleep disorders.

“Confirmation that obese older people are at higher risk of worse outcomes can help improve the screening of patients who use the SUS [Brazil’s national health service], so they get the right care and avoid general deterioration of their health,” Roschel said.

In the coming months, the group will publish the findings of a complementary longitudinal study involving lifestyle therapies designed to prevent negative outcomes in body composition such as loss of muscle mass with body fat gain, and metabolic disorders such as hyperglycemia.

About São Paulo Research Foundation (FAPESP)

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at and visit FAPESP news agency at to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at

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