https://doi.org/10.1016/j.apsb.2023.03.017
This new article publication from Acta Pharmaceutica Sinica B, discusses aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity.
Interleukin (IL)-17A, a pro-inflammatory cytokine, is a fundamental function in the onset and advancement of multiple immune diseases. To uncover the primary compounds with IL-17A inhibitory activity, a large-scale screening of the library of traditional Chinese medicine constituents and microbial secondary metabolites was conducted using splenic cells from IL-17A-GFP reporter mice cultured under Th17-priming conditions.
The results indicated that some aureane-type sesquiterpene tetraketides isolated from a wetland mud-derived fungus, Myrothecium gramineum, showed remarkable IL-17A inhibitory activity. Nine new aureane-type sesquiterpene tetraketides, myrogramins A–I (1, 4–11), and two known ones (2 and 3) were isolated and identified from the strain. Compounds 1, 3, 4, 10, and 11 exhibited significant IL-17A inhibitory activity. Among them, compound 3, with a high fermentation yield dose-dependently inhibited the generation of IL-17A and suppressed glycolysis in splenic cells under Th17-priming conditions. Strikingly, compound 3 suppressed immunopathology in both IL-17A-mediated animal models of experimental autoimmune encephalomyelitis and pulmonary hypertension.
The results revealed that aureane-type sesquiterpene tetraketides are a novel class of immunomodulators with IL-17A inhibitory activity, and hold great promise applications in treating IL-17A-mediated immune diseases.
Keywords: Aureane-type sesquiterpene tetraketides, IL-17A, Experimental autoimmune encephalomyelitis, Pulmonary hypertension
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383523001065-ga1_lrg.jpg
Aureane-type sesquiterpene tetraketides, a novel class of natural immunomodulators with IL-17A inhibitory activity, can be used to treat EAE and animal pulmonary hypertension with a mechanism of glycolysis suppression.
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 19.4
Impact Factor: 14.5
JIF without self-citation: 13.7
ISSN 2211-3835
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Xin Tang, Chuanxi Wang, Lei Wang, Feifei Ren, Runqiao Kuang, Zhenhua Li, Xue Han, Yiming Chen, Guodong Chen, Xiuqing Wu, Jie Liu, Hengwen Yang, Xingzhong Liu, Chen Wang, Hao Gao, Zhinan
Yin, Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity, Acta Pharmaceutica Sinica B, Volume 13, Issue 9, 2023, Pages 3930-3944,
ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2023.03.017