About The Study: In a randomized clinical trial including 524 trauma patients receiving mechanical ventilation with risk factors for developing acute respiratory distress syndrome, the addition of sigh breaths did not significantly increase ventilator-free days. Prespecified secondary outcome data suggest that sighs are well-tolerated and may improve clinical outcomes.
Authors: Richard K. Albert, M.D., of the University of Colorado, Denver, is the corresponding author.
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(doi:10.1001/jama.2023.21739)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being released to coincide with presentation at the European Society of Intensive Care Medicine Lives 2023 36th Annual Congress.
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Journal
JAMA