Involvement of brain peptide dynamics in the pathology of fatty liver disease

Niigata, Japan – The research group of Professor Kamimura in Niigata University have demonstrated the complementary role of peripheral and central nervous system on GH–IGF-1axis activation to prevent MASLD progression. IGF-1 ameliorates fatty infiltration in the liver. Its release is controlled by GH and GH activation is managed by peripheral or central nervous system. However, the role of this axis in MASLD developmental phase has not been well identified. Our study demonstrated that the GH–IGF-1 axis is significant in inhibiting the progression of MASLD. In addition to the peripheral autonomic nervous system activating gastric ghrelin to release GH, hypothalamic BDNF and CRH are keys in central nervous system for GH expression. “IGF-1 release by the nervous system is the key factor in maintaining the pathological homeostasis of MASLD, suggesting its therapeutic potential.” says Prof. Kamimura.