Maternal vaccination against COVID-19 lowered risk of preterm births, Stanford study finds

During the first two years of the pandemic, a COVID-19 infection during pregnancy increased the risk of preterm birth and NICU hospitalizations. However, by 2022, when COVID-19 vaccines were readily available in the United States, this effect disappeared – suggesting that vaccination against the coronavirus may have prevented thousands of preterm births, according to a new study led by Stanford sociologist Florencia Torche.

The study’s findings, published Nov. 27 in the journal Proceedings of the National Academy of Sciences, show how vaccination against COVID-19 may have helped a generation of U.S. children avoid the long-term health issues and costs associated with premature delivery. As previous studies have shown, children who are born prematurely are more likely to encounter educational and economic setbacks later in life.

“The effects of COVID-19 on infant health may be among the most enduring legacies of the pandemic,” said Torche, the Dunlevie Family Professor in the School of Humanities and Sciences. “I hope the study provides strong evidence supporting the benefits of vaccination for the health of the next generation.”

Studying the effects of COVID-19 infection

Torche, along with Jenna Nobles at ​​the University of Wisconsin-Madison, based their study on natality data for California, a diverse and populous state that accounts for 12% of all U.S. births.

In June 2020, California began recording confirmed or presumed cases of COVID-19 infection for all mothers giving birth. This is also when the researchers began their analysis, focusing on facilities with documented, universal testing.

The researchers identified infants with siblings in the California birth records, which allowed them to compare “treated” infants exposed to COVID-19 infection in utero with their “untreated” siblings who did not experience a COVID infection.

The researchers also took into consideration the zip code of the mother’s residence to compare areas that had low and high uptakes of vaccination against COVID-19.

Some of Torche and Nobles’ key findings include:

• Maternal COVID-19 infection increases the probability of preterm delivery, defined as a birth that occurs before 37 weeks of gestation, by 1.2 percentage points, from 7.1 to 8.3%. “This effect is roughly equivalent to in utero exposure to a 9 percentage point increase in the area-level unemployment rate – or to high-intensity wildfire smoke for 20 days – an enormous impact,” the researchers write.
• Maternal COVID-19 infection also led to higher rates of premature delivery before 32 weeks of gestation, resulting in infants facing the highest risk of mortality, morbidity, and developmental difficulties later in life.
• By January 2022, the impacts of COVID-19 on preterm births dropped to zero, but zip codes that had high vaccination rates saw the harmful effects disappear a year earlier than areas with a slower vaccination uptake.

How COVID-19 may exacerbate inequality

Torche and Nobles’ study is one of the first to offer a causal estimate of the impact of maternal COVID-19 infection on neonatal health.

With vaccine rates for the most recent booster hovering at about 7% of U.S. adults, Torche hopes the study emphasizes the importance of staying protected against the virus.

“Unfortunately, even if the adverse impact of COVID-19 infection on preterm birth has plummeted to zero, this adverse impact is likely to emerge again as the virus continues to evolve and mutate, and as vaccine-driven immunity wanes,” Torche said.

The study builds on Torche and Nobles’ previous work that looked at the socioeconomic disparities of the COVID-19 pandemic and its impacts on inequality in the U.S. – an issue Torche is concerned about here, too.

“Barriers to vaccination are higher in disadvantaged and racialized populations, including people with less education and those living in rural areas, i.e. populations that experience much worse infant health even in absence of COVID-19,” Torche said. “This suggests COVID-19 will further exacerbate disparities in infant health in the United States.”

This research was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and by the National Science Foundation (NSF).