interplays
https://doi.org/10.1016/j.apsb.2023.08.009
This new article publication from Acta Pharmaceutica Sinica B, discusses targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays.
The blood–brain barrier (BBB) impairment plays a crucial role in the pathological processes of aging-accompanied neurological diseases (AAND). Meanwhile, circadian rhythms disruption and gut microbiota dysbiosis are associated with increased morbidity of neurological diseases in the accelerated aging population. Importantly, circadian rhythms disruption and gut microbiota dysbiosis are also known to induce the generation of toxic metabolites and pro-inflammatory cytokines, resulting in disruption of BBB integrity. Collectively, this provides a new perspective for exploring the relationship among circadian rhythms, gut microbes, and the BBB in aging-accompanied neurological diseases.
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In this article, the authors focus on recent advances in the interplay between circadian rhythm disturbances and gut microbiota dysbiosis, and their potential roles in the BBB disruption that occurs in AAND. Based on existing literature, potential mechanisms underlying BBB damage induced by dysregulated circadian rhythms and gut microbiota are discussed and proposed, which would serve as the basis for developing potential interventions to protect the BBB in the aging population through targeting the BBB by exploiting its links with gut microbiota and circadian rhythms for treating AAND.
Keywords: Blood–brain barrier, Neurological diseases, Aging, Gut microbiota, Circadian rhythms
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383523003052-ga1_lrg.jpg
This review focuses on the recent advances in the interplay between circadian rhythm disturbances and gut microbiota dysbiosis, and their potential roles in the BBB disruption that occurs in aging-accompanied neurological diseases.
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 19.4
Impact Factor: 14.5
JIF without self-citation: 13.7
ISSN 2211-3835
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Yanping Wang, Weihong Du, Xiaoyan Hu, Xin Yu, Chun Guo, Xinchun Jin, Wei Wang, Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays, Acta Pharmaceutica Sinica B, Volume 13, Issue 12, 2023,
Pages 4667-4687, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2023.08.009