About The Study: In this prespecified secondary analysis of outcomes of 32,000 participants in a randomized clinical trial and post-trial up to 23 years later among adults with hypertension and coronary heart disease risk factors, cardiovascular disease mortality was similar between all three antihypertensive treatment groups (thiazide-type diuretic, calcium channel blocker, or angiotensin-converting enzyme [ACE] inhibitor). ACE inhibitors increased the risk of stroke outcomes by 11% compared with diuretics, and this effect persisted well beyond the trial period.
Authors: Jose-Miguel Yamal, Ph.D., of the University of Texas Health Science Center at Houston, is the corresponding author.
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(doi:10.1001/jamanetworkopen.2023.44998)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Journal
JAMA Network Open