News Release

Updated: Antiphospholipid syndrome

Peer-Reviewed Publication

European Alliance of Associations for Rheumatology (EULAR)

APS is a systemic autoimmune disease associated with persistent antiphospholipid antibodies (aPL). It can cause thrombosis and pregnancy complications as well as non-thrombotic manifestations such as cardiac valve disease.

Classification is important to help identify people to take part in research and ensures that similar disease states are included and compared in trials. This is different to tools that help clinicians make a diagnosis.

The APS classification criteria were last revised in 2006, but since then understanding of the disease has evolved. EULAR and ACR worked together to develop a new APS classification system based on modern disease understanding. The intention was that the new tool would also allow individual criteria and different risk profiles to be weighted and demonstrate excellent operating characteristics with the highest possible specificity. Four key phases in the development of the criteria were followed: generation; item reduction; definition, further reduction, and weighting, threshold identification; and finally, validation.

After reductions and revisions, the updated classification specifies an entry criterion of at least one positive aPL test within 3 years of identification of an aPL-associated clinical criterion. This is followed by a set of weighted criteria, each scoring 1–7 points. The criteria are clustered into six clinical domains and two laboratory domains. The clinical domains are macrovascular venous thromboembolism, macrovascular arterial thrombosis, microvascular, obstetric, cardiac valve, and haematology. The laboratory domains include assays and antibody tests to increase the specificity of the criteria. Patients scoring at least 3 points from each of the clinical and laboratory domains are classified as having APS.

The new classification criteria were tested in potential APS cases, with results showing good sensitivity and specificity. In fact, specificity for the new classification system was 99%, compared to 86% achieved with the original 2006 criteria. This is important, because classification criteria are based on standardised and stringent definitions to ensure consistency in clinical trials, and so very high specificity is required, even at the cost of sensitivity.

EULAR hopes that these new classification criteria will support high-quality, risk-stratified epidemiologic studies and clinical trials in APS, and ultimately lead to improved patient care and management recommendations.



Barbhaiya M, et al. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann Rheum Dis 2023;82:1258–70. doi:10.1136/ard-2023-224609.



EULAR is the European umbrella organisation representing scientific societies, health professional associations and organisations for people with rheumatic and musculoskeletal diseases (RMDs). EULAR aims to reduce the impact of RMDs on individuals and society, as well as improve RMD treatments, prevention, and rehabilitation. To this end, EULAR fosters excellence in rheumatology education and research, promotes the translation of research advances into daily care, and advocates for the recognition of the needs of those living with RMDs by EU institutions.



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