News Release

Maternal diabetes and overweight and congenital heart defects in offspring

JAMA Network Open

Peer-Reviewed Publication

JAMA Network

About The Study: This study of 620,000 children found that maternal type 1 diabetes was associated with increased risk for most types of congenital heart defects in offspring, while obesity and overweight were associated with increased risk for complex defects and outflow tract obstruction and decreased risk for ventricular septal defects. These different risk profiles of type 1 diabetes and overweight and obesity may suggest distinct underlying teratogenic mechanisms. 

Authors: Riitta Turunen, M.D., Ph.D., and Emmi Helle, M.D., Ph.D., of the University of Helsinki, are the corresponding authors. 

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Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

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