News Release

Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

Peer-Reviewed Publication

Compuscript Ltd

https://doi.org/10.1016/j.apsb.2023.08.019

 

This new article publication from Acta Pharmaceutica Sinica B, discusses mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy.

 

Gas therapy is emerging as a highly promising therapeutic strategy for cancer treatment. However, there are limitations, including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision, associated with gas therapy.

 

The authors of this article developed a series of photoactivatable nitric oxide (NO) donors NRh-R-NO (R = Me, Et, Bn, iPr, and Ph) based on an N-nitrosated upconversion luminescent rhodamine scaffold. Under the irradiation of 808 nm light, only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence (FUCL) signal at 740 nm, ascribed to lower N–N bond dissociation energy.

 

The involved multistage near-infrared-controlled cascade release of gas therapy was also investigated, including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation, the superoxide anion O2 produced by the photodynamic therapy (PDT) effect of NRh-Ph, and highly toxic peroxynitrite anion (ONOO) generated from the co-existence of NO and O2. After mild nano-modification, the nanogenerator (NRh-Ph-NO NPs) empowered with superior biocompatibility could target mitochondria. Under an 808 nm laser irradiation, NRh-Ph-NO NPs could induce NO/ROS to generate RNS, causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation, which further induced tumor immunogenic cell death (ICD).

 

 In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy, demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL imaging. Collectively, this versatile strategy defines the targeted RNS-mediated cancer therapy.

 

 

Keywords: Near infrared, Photo-triggered, Mitochondrion, Upconversion luminescent bioimaging, Peroxynitrite, Nanogenerator, Gas therapy, In vivo

Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383523003258-ga1_lrg.jpg

The peroxynitrite upconversion nanogenerator NRh-Ph-NO nanoparticles empowered with superior mitochondrial targeting could induce reactive nitrogen species-potentiated precision gas therapy guided by frequency upconversion luminescence imaging upon 808 nm laser irradiation.

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 19.4

Impact Factor: 14.5

JIF without self-citation: 13.7

ISSN 2211-3835

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Hui Yu, Aliya Tiemuer, Xufeng Yao, Mingyuan Zuo, Hai-Yan Wang, Yi Liu, Xiaoyuan Chen, Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy, Acta Pharmaceutica Sinica B, Volume 14, Issue 1, 2024, Pages 378-391, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2023.08.019


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