Hypoxia visualized by endoscopic imaging as an objective indicator for assessing bowel urgency and ulcerative colitis disease activity

Tsukuba, Japan—Ulcerative colitis (UC) is a chronic colitis of indeterminate origin, characterized by continuous inflammation spreading from the rectum. Common symptoms include diarrhea, bloody stool, and bowel urgency. The initial treatment goal is to alleviate these clinical symptoms; however, the ultimate aim is to achieve a thorough resolution of the endoscopic inflammation of the colonic mucosa. Despite the high prevalence of bowel urgency in UC patients and its substantial impact on their quality of life, there are limited tools for its objective evaluation. Currently, a scoring system is employed during colonoscopy to evaluate the severity of colitis, but this method is subject to variability in interpretation among physicians, complicating the objective assessment of disease activity.

In this study, researchers at University of Tsukuba have investigated hypoxia in the inflamed colonic mucosa of UC patients. Inflammation leads to oxygen depletion in the mucosa as inflammatory cells consume substantial oxygen, and mucosal blood flow decreases due to microvascular dysfunction. By performing hypoxia imaging colonoscopy on UC patients and measuring the oxygen saturation in their colonic mucosa, they discovered a correlation between the severity of clinical symptoms, particularly bowel urgency and reduced oxygen saturation in the rectal mucosa. Further analysis showed that the lower oxygen saturation in the colonic mucosa was associated with greater severity of colitis, as assessed by endoscopy or microscopy.

These findings suggest that the oxygen saturation values obtained from hypoxia imaging colonoscopy can be utilized to evaluate both bowel urgency and the severity of ulcerative colitis. This method promises to offer a highly objective measure of UC disease activity.

_{Original Paper}

Title of original paper:
Clinical Usefulness of Hypoxia Imaging Colonoscopy for the Objective Measurement of Ulcerative Colitis Disease Activity

Journal:
Gastrointestinal Endoscopy

DOI:
10.1016/j.gie.2023.12.035

_{Correspondence}

Assistant Professor AKIYAMA, Shintaro
Professor TSUCHIYA, Kiichiro
Institute of Medicine, University of Tsukuba

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Institute of Medicine