Ear clip stimulation of vagus nerve shows promise as POTS treatment, according to OU College of Medicine study

A newly published study from the University of Oklahoma College of Medicine at OU Health Sciences shows that stimulating the body’s longest nerve through a clip on the ear significantly lessens the woozy symptoms of POTS, or postural tachycardia syndrome.

People who suffer from POTS experience symptoms every time they stand up after they’ve been sitting or lying down — dizziness, palpitations and a dramatic increase in heart rate are among the most common. Millions of people suffer from POTS, and it has increased significantly since the onset of the COVID-19 pandemic because the virus can affect the heart.

The new study is led by Stavros Stavrakis, M.D., Ph.D., an associate professor of cardiology in the OU College of Medicine. The study focused on the vagus nerve, sometimes called the body’s “superhighway” because it controls functions such as digestion, breathing and heart rate. As the longest nerve in the body, the vagus begins in the brain, runs through the heart and lungs, and ends in the intestines — and it can be stimulated on the outside of the ear.

About half of the study participants were given an electrical stimulation device with a clip they placed on the tragus, which is the small piece of cartilage outside the ear canal. The device delivered a low-level electrical stimulation to the vagus nerve. Participants used the device for one hour each day for two months. The other half of the participants, the control group, received a placebo treatment. The study was double-blinded, meaning neither the participants nor the researchers knew which patients were receiving the real treatment.

Stavrakis and his research team discovered that POTS symptoms were significantly lessened in people receiving vagus nerve stimulation. Their heart rates still increased upon standing, but not as much — 15 beats less per minute than without the stimulation. In addition, they discovered that the treatment decreased the surge of adrenaline in the body and the level of inflammation in the blood, which also contributes to POTS.

“There is a lot of excitement about vagus nerve stimulation in the field of cardiology,” Stavrakis said. “It is non-invasive and inexpensive, and it doesn’t have side effects the way medication would. I’m optimistic that it will become a treatment that can help improve the quality of life for people with POTS.”

The study was published in JACC: Clinical Electrophysiology, a prestigious journal of the American College of Cardiology. Stavrakis also presented the results of his study as a late-breaking clinical trial at the annual meeting of the Heart Rhythm Society.

Stavrakis has researched vagus nerve stimulation for about 15 years. He first studied its use for treating atrial fibrillation (an irregular heartbeat), discovering that vagus nerve stimulation decreased atrial fibrillation by 85% when patients were monitored compared to those who didn’t receive the treatment. His next steps are to conduct larger clinical studies for both POTS and atrial fibrillation to better understand how the treatment works, which patients are best suited for the treatment, and how long its benefits last.

Vagus nerve stimulation is somewhat unusual in a complex medical field like cardiology, but its promise is its ease of use and affordability. Stavrakis envisions a future where people with conditions like POTS could wear a wireless stimulation device resembling an ear pod.

“With advancements in technology, people could be listening to music on their phone while also stimulating their vagus nerve,” he said. “We’re not there yet, but I think it’s the way of the future.”

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About the OU College of Medicine

Founded in 1910, the OU College of Medicine at the University of Oklahoma Health Sciences trains the next generation of health care professionals. The OU Health Sciences is the academic partner of OU Health, the state’s only comprehensive academic health system of hospitals, clinics and centers of excellence. With campuses in Oklahoma City and Tulsa, the College of Medicine offers the state’s only Doctor of Medicine degree program and a nationally competitive Physician Assistant program. For more information, visit medicine.ouhsc.edu.

About the University of Oklahoma Health Sciences 

The University of Oklahoma Health Sciences is one of the nation’s few academic health centers with all health professions colleges — Allied Health, Dentistry, Medicine, Nursing, Pharmacy, Public Health, Graduate Studies and School of Community Medicine. OU Health Sciences serves approximately 4,000 students in more than 70 undergraduate and graduate degree programs on campuses in Oklahoma City and Tulsa and is the academic and research partner of OU Health, the state’s only comprehensive academic health care system. OU Health Sciences is ranked 129 out of over 2,849 institutions in funding received from the National Institutes of Health, according to the Blue Ridge Institute for Medical Research. For more information, visit ouhsc.edu.