News Release

Study reveals positive outcomes of pharmacy care management service for medically complex medicare advantage members

Findings include lower care costs, less inpatient stays, and better adherence to meds

Peer-Reviewed Publication

UPMC Health Plan



Denise Hughes

UPMC Health Plan

C 412-983-3836


Thayer Montague


T 571-414-8987


Study Reveals Positive Outcomes of Pharmacy Care Management Service for Medically Complex Medicare Advantage Members

Findings Include Lower Care Costs, Less Inpatient Stays, and Better Adherence to Meds

PITTSBURGH (March 4, 2024)—A high-touch pharmacy care management (PCM) service leads to lower pharmacy spending costs, decreased inpatient hospital stays and optimal medication use for Medicare Advantage (MA) members identified as being at high risk, according to recent research published in NEJM Catalyst.

The analysis, conducted by a research team from UPMC Health Plan and RxAnte, validates that the added costs of a targeted program that includes pharmacist care management, medication reconciliation and medication in easy-to-use packaging delivered to the patient’s home lowers net costs while improving medication adherence and member satisfaction.

“We learned that an analytically targeted, coordinated and thoughtful Pharmacy Care Management approach can help Medicare Advantage members save money and improve their health outcomes,” said co-author Chronis Manolis, R. Ph., chief pharmacy officer at UPMC Health Plan. “In addition to helping individual patients, this ultimately lowers downstream health care costs and utilization.”

The goal of the study was to investigate the impact of an integrated PCM program for MA beneficiaries taking multiple chronic medications, including a subset with high predicted cost savings from improved medication adherence, assessed using the Value of Future Adherence (VFAÒ) score. A total of 724 members receiving PCM services were matched to 3,620 control members who received usual pharmacy care. The average PCM participant was 68 years old and 38% were male. Participants took an average of 11 maintenance medications daily.

On average, PCM program participants decreased medical spending by a net of $108 per enrollee, per month compared to their counterparts who weren’t in the program. This savings was $406 per enrollee, per month for patients with a high VFA score at baseline. In addition, PCM participants experienced 15% fewer inpatient stays compared with their counterparts and more than doubled to 32% fewer inpatient stays for members with a high VFA score.

To conduct this analysis, the research team designed, implemented and evaluated the effect of Mosaic Pharmacy Service’s PCM program for UPMC’s Medicare Advantage members with multiple chronic conditions. Mosaic is a subsidiary of RxAnte, a portfolio company of UPMC Enterprises since 2016. UPMC Health Plan has been a customer of RxAnte since 2013.

All members enrolled in the PCM program participated in a tele-onboarding appointment to confirm their medication history, review and reconcile current prescriptions, and synchronize medication refills. Mosaic Pharmacy Service dispensed medications, including home delivery in 30-day cycles, and provided ongoing data-driven clinical pharmacy services for the PCM program to ensure comprehensive and consistent pharmacy care.

Adjudicated claims data from a 12-month follow-up period were used to retrospectively evaluate the cost, health care utilization and medication adherence outcomes for MAPD members participating in the PCM program. Researchers then compared this group’s outcomes to those from a matched (control) group of MAPD plan members receiving standard pharmacy care.

“One of the challenges for Medicare Advantage health plans is that enrollment is increasing among medically complex and vulnerable populations. It's getting harder to manage cost of care, as these members can be difficult to engage and build relationships with. Traditional pharmacies are not meeting the clinical needs of the complex and vulnerable senior population.” said co-author Josh Benner, Pharm.D., Sc.D., founder, and CEO of RxAnte. “Building on these results, Mosaic is now available broadly as a value-based pharmacy service for high-risk Medicare Advantage plans nationwide.”

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About UPMC Insurance Services

UPMC Insurance Services serves nearly 4.5 million members and is owned and operated by UPMC, a world-renowned health care provider and insurer in Pittsburgh, Pennsylvania. UPMC Insurance Services provides commercial products through UPMC Health Plan for both groups and individuals. Its commercial products also include workers' compensation and employee assistance from nationally known Workpartners®. Government products include Medicare Advantage plans (UPMC for Life); special needs plans for those who are eligible for Medicare and Medical Assistance (UPMC for Life Complete Care and UPMC Community HealthChoices); a Medical Assistance plan (UPMC for You); and Children's Health Insurance Program plans (UPMC for Kids). Community Care Behavioral Health Organization—one of the nation's largest nonprofit managed care behavioral health organizations—is also part of the Insurance Services Division. Community Care offers a full range of services to commercial and Medical Assistance members. For more information, visit

About RxAnte

From its founding in 2011, RxAnte's mission has been exceedingly simple: Get more from medicines. Today, we are the leading provider of predictive analytics and targeted clinical programs that improve medication prescribing and adherence. With over 30 million lives under management, our patented solutions for health plans and value-based providers are proven to improve quality scores and lower costs by improving prescription drug use. A key component of RxAnte's offering is its Mosaic Pharmacy Service, which provides value-based, in-home pharmacy services to medically complex and vulnerable seniors. Mosaic directly improves prescribing, adherence, and drug therapy outcomes for patients under our care with the objective of improving quality and lowering total cost of care.




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