Article Highlight | 12-Mar-2024

Neutrophil-to-lymphocyte ratio as an effective biomarker for meningioma: a systematic review and meta-analysis

Xia & He Publishing Inc.

Background and objectives

Previous studies showed that tumors are associated with the increased inflammatory burden and neutrophil-to-lymphocyte ratio (NLR) is also associated with inflammatory conditions. However, there is no review on the role of NLR in meningioma. The goal of this study was to see if NLR has any prognostic and diagnostic value in meningioma.



The search was conducted on PubMed, Scopus, and Web of Science up to 3 August 2023. A total of 23 studies were included in the systematic review, of which 13 were included in the meta-analysis.



It was found that patients with high-grade meningioma had higher levels of NLR compared to those with low-grade meningioma (standardized mean difference [SMD] = 0.72, 95% confidence interval [CI]: 0.21–1.23, p = 0.006)]. In addition, we found that there was no difference between NLR levels of patients with meningioma and those with gliomas (SMD, −0.19, 95% CI: −0.47–0.10, p = 0.20). Also, higher levels of NLR were found in patients with meningioma compared with healthy controls (SMD = 0.56, 95% CI: 0.24–0.88, p = 0.01). Studies showed that an NLR > 2.4 differentiated high-grade and low-grade meningioma, an NLR > 2.74 differentiated high and low progression-free survival groups, and an NLR > 2.59 was associated with recurrence, with high sensitivity and specificity. However, the NLR did not predict postoperative pneumonia following meningioma resection. Because of the contradiction, our study did not clearly demonstrate the difference in NLR levels in meningioma and other pathologies, so more studies are needed on this subject.



NLR had significant diagnostic and prognostic value in meningioma. In general, we inferred a strong link between systemic inflammation assessed by NLR and meningioma, based on elevated levels of NLR in patients with meningioma compared to healthy controls. In addition, NLR had significant predictive potential for the progression and recurrence of meningioma. The predictive potential increased when combined with other diagnostic tools such as fibrinogen level. NLR may guide clinical decision making as an inflammatory marker and its relationship to therapeutic efficacy.


The study was recently published in the Exploratory Research and Hypothesis in Medicine.

Exploratory Research and Hypothesis in Medicine (ERHM) publishes original exploratory research articles and state-of-the-art reviews that focus on novel findings and the most recent scientific advances that support new hypotheses in medicine. The journal accepts a wide range of topics, including innovative diagnostic and therapeutic modalities as well as insightful theories related to the practice of medicine. The exploratory research published in ERHM does not necessarily need to be comprehensive and conclusive, but the study design must be solid, the methodologies must be reliable, the results must be true, and the hypothesis must be rational and justifiable with evidence.


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