About The Study: Among self-reported Black individuals, male and female V142I carriers faced similar and substantial risk for heart failure hospitalization, predominantly with reduced ejection fraction, and death, with steep age-dependent penetrance. Delineating the individual contributions of, and complex interplay among, the V142I variant, ancestry, the social construct of race, and biological or social determinants of health to cardiovascular disease merits further investigation.
Corresponding Author: To contact the corresponding author, Scott D. Solomon, M.D., email ssolomon@rics.bwh.harvard.edu.
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(doi:10.1001/jama.2024.4467)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: The study is being released to coincide with presentation at the European Society of Cardiology-Heart Failure Congress.
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Journal
JAMA