News Release

Nirmatrelvir-ritonavir and symptoms in adults with postacute sequelae of SARS-CoV-2 infection

JAMA Internal Medicine

Peer-Reviewed Publication

JAMA Network

About The Study: The results of this randomized clinical trial showed that a 15-day course of nirmatrelvir-ritonavir in a population of patients with postacute sequelae of SARS-CoV-2 infection (PASC) was generally safe but did not demonstrate a significant benefit for improving select PASC symptoms in a mostly vaccinated cohort with protracted symptom duration. Further studies are needed to determine the role of antivirals in the treatment of PASC. 

Corresponding Author: To contact the corresponding authors, email Linda N. Geng, M.D., Ph.D. ( and Upinder Singh, M.D. (

To access the embargoed study: Visit our For The Media website at this link 


Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: This study is being presented at the Demystifying Long COVID North American Conference 2024. 

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