News Release

Pilot study in JNCCN explores new approach for reducing anxiety and improving quality of life after stem cell transplantation

Researchers at Brigham and Women’s Hospital and Dana-Farber Cancer Institute found significant uptake and scalability in phone-based “PATH” intervention to improve psychological well-being in blood cancer patients.

Peer-Reviewed Publication

National Comprehensive Cancer Network

Dr. Amonoo


Hermioni L. Amonoo, MD, MPP, MPH, Brigham and Women’s Hospital/Dana-Farber Cancer Institute.

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Credit: NCCN

PLYMOUTH MEETING, PA [June 11, 2024] — New research in the June 2024 issue of JNCCN—Journal of the National Comprehensive Cancer Network highlights a promising approach for alleviating distress, enhancing quality of life, improving physical function, and reducing fatigue in patients with blood cancers who undergo hematopoietic stem cell transplantation (HSCT). The study used a randomized clinical trial to evaluate the feasibility of a nine-week, phone-delivered, positive psychology program called Positive Affect for the Transplantation of Hematopoietic stem cells intervention (PATH), that was specifically tailored to the needs of this population. The findings indicate that the PATH intervention is both feasible and well-received by this patient population, as most of the patients (91%) who received the PATH intervention completed all of the intervention sessions and found them easy and helpful.

“Having 9 out of 10 people complete all the sessions is great,” explained lead researcher Hermioni L. Amonoo, MD, MPP, MPH, Brigham and Women’s Hospital/Dana-Farber Cancer Institute. “We designed PATH with the needs of HSCT survivors in mind. First, PATH is accessible to patients, as they can learn the skills and engage with the intervention over phone from wherever they are—eliminating the need to travel to the cancer center. Second, the weekly exercises can be completed by patients at their convenience using the PATH manual, which guides patients on how to use the exercises and skills. This means that the actual phone sessions only last 15-20 minutes, in contrast to other well-established psychotherapies like cognitive behavioral therapy, which typically last 60-90 minutes per session. Third, we carefully curated the intervention sessions based on which activities patients can safely engage in while their immune system recovers following the transplant. For instance, unlike in other medical populations, we did not include exercises that focus on community service, which might unnecessarily expose patients to risks.”

The pilot study was conducted at the Brigham and Women’s Hospital/Dana-Farber Cancer Institute from August 2021 to August 2022. A total of 70 adult patients with blood cancers who have received HSCT, were randomized into two groups, with the intervention beginning about 100 days after HSCT. Those randomized into the PATH arm participated in a variety of weekly positive psychology exercises focused on gratitude, personal strengths, and meaning. Not only was participation high—94% completed at least six of the nine sessions and 91% completed all nine—the intervention had promising effects on patient-reported outcomes immediately after completion of the program and again at week 18.

Dr. Amonoo added: “Cancer care providers should consider the potential benefits of psychosocial resources and interventions like PATH that focus on enriching positive emotions to bolster their patients’ well-being. While the active identification and treatment of psychological distress, like anxiety, in patients with cancer are crucial, encouraging patients to engage in simple, structured, and systematic exercises aimed at fostering positive thoughts and emotions, such as gratitude, has the potential to enhance well-being as well.”

“This positive psychology intervention highlights the importance of not only screening for distress but the promise of creating mechanisms that enhance well-being and reduce distress in our patients,” commented Jessica Vanderlan, PhD, Manager, Siteman Psychology Service, Licensed Clinical Psychologist, Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, Vice Chair of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Panel for Distress Management—who was not involved in this research. “Development of clinical interventions that are brief (15-20 minutes) and delivered by phone could greatly improve patient access to care. This type of accessibility is important in an oncology population, especially in acute recovery periods with many competing demands and physical symptoms.”

To read the entire study, visit Complimentary access to “A Positive Psychology Intervention in Allogeneic Hematopoietic Stem Cell Transplantation Survivors (PATH): A Pilot Randomized Clinical Trial” is available until September 10, 2024.

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About JNCCN—Journal of the National Comprehensive Cancer Network
More than 25,000 oncologists and other cancer care professionals across the United States read JNCCN—Journal of the National Comprehensive Cancer Network. This peer-reviewed, indexed medical journal provides the latest information about innovation in translational medicine, and scientific studies related to oncology health services research, including quality care and value, bioethics, comparative and cost effectiveness, public policy, and interventional research on supportive care and survivorship. JNCCN features updates on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), review articles elaborating on guidelines recommendations, health services research, and case reports highlighting molecular insights in patient care. JNCCN is published by Harborside/BroadcastMed. Visit To inquire if you are eligible for a FREE subscription to JNCCN, visit Follow JNCCN at

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, equitable, and accessible cancer care so all patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit for more information.

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