About The Study: Among adults in the intensive care unit who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions. The current evidence presents a high degree of certainty for clinicians to consider prolonged infusions as a standard of care in the management of sepsis and septic shock.
Corresponding Author: To contact the corresponding author, Jason A. Roberts, B.Pharm., Ph.D., email j.roberts@uq.edu.au.
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(doi:10.1001/jama.2024.9803)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the Critical Care Reviews Meeting 2024.
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Journal
JAMA