Plantaricin LD1 inhibits the growth and biofilm formation of Staphylococcus aureus in Milk
Xia & He Publishing Inc.
Background and objectives
Bacteriocins of probiotic lactic acid bacteria have been used as bio-preservatives to improve food safety and extend the storage period of some food types. This study explored the impact of plantaricin LDL, a bacteriocins purified from the potential probiotic strain, Lactobacillus plantarum LD1, on inhibiting the growth and biofilm formation of food spoilage bacteria in milk.
Methods
The antimicrobial and anti-biofilm activity of Plantaricin LD1 was determined against a food-borne pathogen, Staphylococcus aureus subsp. aureus ATCC 25923. The efficacy of plantaricin LD1 against S. aureus subsp. aureus ATCC 25923 was also tested in the milk.
Results
Plantaricin LD1 had a minimum inhibitory concentration of 79.16 µg/mL and minimum bactericidal concentration of 158.33 µg/mL against S. aureus subsp. aureus ATCC 25923. Biofilm formation of S. aureus subsp. aureus ATCC 25923 was completely inhibited in the presence of 79.16 µg/mL of plantaricin LD1. Complete loss of cell viability in milk was observed after treatment with double minimum inhibitory concentration (158.33 µg/mL) of plantaricin LD1 at 48 hrs.
Conclusions
Plantaricin LD1 purified from food isolate of L. plantarum LD1 has antimicrobial and anti-biofilm activity against the food-borne pathogen, S. aureus subsp. aureus ATCC 25923. Plantaricin LD1 treated milk remained fresh by inhibiting the cell viability of S. aureus subsp. aureus ATCC 25923. Therefore, plantaricin LD1 may be used as a natural food bio-preservative for the safety of milk.
Full text
https://www.xiahepublishing.com/2572-5505/JERP-2023-00011
The study was recently published in the Journal of Exploratory Research in Pharmacology.
Journal of Exploratory Research in Pharmacology (JERP) publishes original innovative exploratory research articles, state-of-the-art reviews, editorials, short communications that focus on novel findings and the most recent advances in basic and clinical pharmacology, covering topics from drug research, drug development, clinical trials and application.
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