https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/14/issue/9

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

 

Recent advances to address challenges in extracellular vesicle-based applications for lung cancer by Gaigai Huang, Wenshu Zheng, Yu Zhou, Meihua Wan and Tony Hu (https://doi.org/10.1016/j.apsb.2024.06.010). This review discusses lung cancer management challenges and explores the potential of extracellular vesicles (EVs) for personalized treatment and diagnosis, focusing on enhancing clinical translation through advanced engineering technologies.

 

Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke by Ru Li, Riqing Wei, Chenxin Liu et al. (https://doi.org/10.1016/j.apsb.2024.05.007). This study elucidates the intricate molecular mechanisms underpinning heat stroke-induced liver injury, highlighting the diverse responses of Kupffer cell (KC) subsets and the pivotal role of HMOX-1 in orchestrating ferroptosis in KCs, particularly in KC2, and NLRP3 inflammasome activation.

 

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH by Ziqi Huang, Kun Zhang, Yurui Jiang et al. (https://doi.org/10.1016/j.apsb.2024.06.001). A novel "molecular glue", LXH-3-71, was discovered to degrade PHGDH by facilitating formation of the dynamic chimera between PHGDH and DDB1-CRL E3 ligase in CRC cells.

 

In situ tumor vaccine with optimized nanoadjuvants and lymph node targeting capacity to treat ovarian cancer and metastases by Yuan Li, Fan Tong, Yufan Wang et al. (https://doi.org/10.1016/j.apsb.2024.06.003). A smart tumor in situ nano-vaccine Tra/CpG@Man-P/Gel was constructed, and the size of nanoadjuvants was optimixed, to induce potent antitumor immunity and inhibit the primary and metastatic tumors.

 

 

Other articles include:

 

Review Articles

Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment

Aaron T. Kao, Christian V. Cabanlong, Kendra Padilla, Xiang Xue

Current status and trends in small nucleic acid drug development: Leading the future

Yuxi Miao, Chen Fu, Zhaojin Yu, Lifeng Yu, ... Minjie Wei

Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges

Xiaokun Zhang, Ye Wu, Jiayi Lin, Shengxin Lu, ... Xin Luan

Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Yunna Chen, Qianqian Zhou, Zongfang Jia, Nuo Cheng, ... Lei Wang

Transepithelial transport of nanoparticles in oral drug delivery: From the perspective of surface and holistic property modulation

Yaxian Zheng, Shiqin Luo, Min Xu, Qin He, ... Yuan Huang

 

Original Articles

Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance

Yumeng Wang, Chengxi Li, Jianping Li, Shu Zhang, ... Jianming Guo

Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation

Zezhong Mou, Yiling Chen, Jinzhong Hu, Yun Hu, ... Haowen Jiang

Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

Wenkang Fu, Yanyan Lin, Mingzhen Bai, Jia Yao, ... Wenbo Meng

Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism

Bin Li, Qi Xiao, Hongmei Zhao, Jianuo Zhang, ... Haitao Liu

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

Weilian Bao, Jiaren Lyu, Guize Feng, Linfeng Guo, ... Xiaoyan Shen

Discovery and evaluation of a novel ¹⁸F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

Junqi Hu, Yinlong Li, Chenchen Dong, Huiyi Wei, ... Weijian Ye

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

Chris Chun-Yiu Chan, Qian Guo, Jasper Fuk-Woo Chan, Kaiming Tang, ... Shuofeng Yuan

Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng

Ke Zhang, Jinru Jia, Ting Li, Wenjing Liu, ... Yuelin Song

CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

Xiaoyu Wu, Zijun Bai, Hui Wang, Hanqing Wang, ... Weiwei Tao

An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy

Mengru Cai, Tingting Fu, Rongyue Zhu, Panxiang Hu, ... Jian Ni

Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy

Zaigang Zhou, Wenjuan Luo, Chunjuan Zheng, Haoxiang Wang, ... Jianliang Shen

Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption

Mengyi Yan, Xiayun Chen, Xiaotong Li, Qianqian Liu, ... Shiying Li

Establishing cell suitability for high-level production of licorice triterpenoids in yeast

Wentao Sun, Shengtong Wan, Chuyan Liu, Ruwen Wang, ... Chun Li

Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

Xinyun Jian, Cheng Wang, Shijuan Wu, Guo Sun, ... Yuhui Sun

 

Short Communication

SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

Kaixiang Zhu, Lili Song, Linyue Wang, Lei Hua, ... Sheng Cui

 

Letters to the Editor

Allosteric regulation of Keap1 by 8β-hydroxy-α-cyclocostunolide for the treatment of acute lung injury

Juan Zhang, Min Zhang, Qi-Meng Zhu, Xin-Rong Xu, ... Cheng-Peng Sun

Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants

Mingkun Huang, Yufang Hu, Ling Zhang, Hua Yang, ... Wei Sun

 

Highlights

Advancing cancer nanomedicine with machine learning

Xifeng Qin, Tun Lu, Zhiqing Pang

PEGylated bacteria restore intestinal mucosal barrier

Menghang Zu, Xue Xia, Bo Xiao

Jun12682, a potent SARS-CoV-2 papain-like protease inhibitor with exceptional antiviral efficacy in mice

Mianling Yang, Meehyein Kim, Peng Zhan

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 22.4

Impact Factor: 14.7 (Top 5 journal in the category of Pharmacology and pharmacy)

JIF without self-citation: 13.9

 

ISSN 2211-3835

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