About The Study: In asymptomatic patients with severe aortic stenosis and myocardial fibrosis, early aortic valve intervention had no demonstrable effect on all-cause death or unplanned aortic stenosis–related hospitalization. The trial had a wide 95% CI around the primary end point, with further research needed to confirm these findings.
Corresponding Author: To contact the corresponding author, Marc R. Dweck, PhD, email marc.dweck@ed.ac.uk.
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(doi:10.1001/jama.2024.22730)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Journal
JAMA