Safety and outcomes of bronchoscopic lung volume reduction with endobronchial valves under moderate sedation

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Key findings

• Bronchoscopic lung volume reduction (BLVR) done under moderate sedation (MS) may have lower rate of complications especially pneumothorax as compared to what is quoted in literature when procedure is done under general anesthesia.

What is known and what is new?

• BLVR can be safely performed under MS with similar efficacy as demonstrated in LIBERATE trial.

• We report that BLVR done under MS may have significantly lower rates of pneumothorax than quoted in literature.

What is the implication, and what should change now?

• Larger studies are needed to confirm the findings of our study.

• If our findings are confirmed in larger study, it may potentially change practice of how BLVR is performed.

Publication: Reinoso JL, Mallah H, Sutchu S, DiRico M, Patel P, Vijayan K, Mehta HJ. Safety and outcomes of bronchoscopic lung volume reduction with endobronchial valves under moderate sedation. J Thorac Dis 2025;17(2):641-649. doi: 10.21037/jtd-24-1707