image: Kathryn Sullivan, MD, pulmonologist at the School of Medicine at the University of California, San Francisco.
Credit: Kathryn Sullivan, MD
EMBARGOED UNTIL: 8:15 a.m., Wednesday, May 21, 2025
Session: D13—Current Research in Critical and Acute Care
Neighborhood Health Measured by the Healthy Places Index (HPI), but Not by the Area Deprivation Index (ADI), Is Associated with Mortality for Critically Ill Sepsis Patients in the San Francisco Bay Area
Date and Time: Wednesday, May 21, 2025, 8:15 a.m.
Location: Room 25, Hall E (North Building, Exhibition Level), Moscone Center
ATS 2025, San Francisco – Living in a disadvantaged neighborhood is linked to worse health outcomes, but there are significant differences in how socioeconomic determinants of health are measured. Now new research presented at the ATS 2025 International Conference finds that a widely used socioeconomic index may not accurately classify patients who live in areas with a high cost of living.
Researchers found the Area Deprivation Index (ADI) incorrectly classified a struggling San Francisco neighborhood as highly advantaged, while the Healthy Places Index (HPI) provided a more accurate assessment of the neighborhood. They also found that the HPI was a better predictor of mortality risk for patients hospitalized with sepsis.
“On a national level and in statewide studies, the ADI is a well validated measure, but its utility is limited in our cohort,” said first author Kathryn Sullivan, MD, a pulmonologist at the School of Medicine at the University of California, San Francisco. “Understanding why this is the case can help us improve our measurement tools.”
The ADI is one of the most widely used area-based socioeconomic measures and is used by the Center for Medicare and Medicaid Services to calculate funding for accountable care organizations. However, a 2023 study in New York suggested that the index may overemphasize home value, raising the concern that in areas with high housing costs, home values could outweigh other components of the index, potentially masking other challenges in the neighborhood.
Sullivan noted that when researchers applied the ADI to San Francisco neighborhoods with a high cost of living where residents struggled with poverty and access to resources, the index classified them as living in one of the most highly advantaged neighborhoods in the country.
For the new study, researchers gathered data from almost 900 critically ill patients with sepsis who were admitted through the emergency departments of two San Francisco hospitals. They used both ADI and HPI to classify each patient’s home address and compared this classification with the patient’s outcomes.
They found a large disparity in how the two indices classified which patients were living in the most disadvantaged neighborhoods. They also found that living in the most disadvantaged neighborhood as measured by the HPI — but not the ADI — was significantly associated with a patient’s risk of dying in the hospital, Dr. Sullivan said.
“Our findings indicate that the ADI is not functioning as intended in our cohort when compared to another measure of neighborhood advantage, which was a better predictor of outcomes in this case,” she said.
The study highlights the need to continue to refine and optimize tools like the ADI and HPI, especially when these indices are used to make decisions about how to allocate health care resources, she said. In addition, while neighborhood disadvantage has previously been associated with negative health outcomes for chronic diseases, the study provides new insights into how these factors can influence health for acute and even critical illnesses, Dr. Sullivan added.
The team hopes to do follow-up research to better understand why the ADI did not perform as expected in this region. They also plan to repeat their analysis in a different region with more rural participants.
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CONTACT FOR MEDIA:
Dacia Morris
Suzanne Leigh
suzanne.leigh@ucsf.edu