AI tool enables real-world assessment of eczema severity via smartphone photos

Tokyo, Japan – [May 9, 2025] – A team of researchers from Keio University School of Medicine, Kyoto Prefectural University of Medicine, and Teikyo University, in collaboration with Atopiyo LLC, has developed a novel artificial intelligence (AI) model that can objectively assess eczema severity using smartphone images uploaded by patients. Their findings were recently published in Allergy, the official journal of the European Academy of Allergy and Clinical Immunology.

Atopic dermatitis (AD) is a common chronic skin condition that flares repeatedly and often requires long-term monitoring and treatment adjustments. In recent years, smartphone apps and social media platforms have made it easier for patients to track their symptoms, learn about their condition, and document changes over time. However, patient-reported symptoms like itch or sleep loss don’t always align with visible disease severity. This gap underscores the need for more standardized, objective evaluation tools—and highlights the growing potential of digital biomarkers to fill that role.

To address this, the research team leveraged data from Atopiyo, Japan’s largest AD platform, where over 28,000 users have shared more than 57,000 symptom photos and personal comments since 2018. The AI model developed in this study integrates three key algorithms: body part detection, eczema lesion detection, and severity scoring using the Three Item Severity (TIS) scale, which evaluates redness, swelling, and excoriation.

Using a training dataset of 880 images with self-reported itch scores, the AI model demonstrated high diagnostic accuracy. In a validation study using 220 test images, the AI-based TIS (AI-TIS) showed a strong correlation with dermatologist-assessed TIS scores (R = 0.73, P < 0.001) and a meaningful correlation with objective SCORAD scores (R = 0.53, P = 0.04).

“Many patients with eczema struggle to evaluate their disease severity on their own,” said Dr. Takeya Adachi, the study's corresponding author. “Our AI model allows for objective, real-time tracking using just a smartphone, empowering patients and potentially improving disease management.”

Interestingly, the study also found that AI-derived severity scores correlated only weakly with self-reported itch scores, highlighting the discrepancy between perceived symptoms and observable inflammation. This supports the growing need for digital biomarkers that can enhance precision in dermatological care.

The researchers aim to expand the model's utility by incorporating broader skin types, age ranges, and integrating additional clinical features from scoring systems like SCORAD and EASI. This work paves the way for AI-driven teledermatology solutions that support both patients and clinicians in real-world settings.

About the Study:
The study titled “AI-based objective severity assessment of atopic dermatitis using patient photos in a real-world setting: a digital biomarker approach” was published in Allergy, May 20, 2025.
Corresponding author: Dr. Takeya Adachi (Keio University School of Medicine)
Email: jpn4156@me.com

Funding:
This research was supported by the Ministry of Health, Labour and Welfare (Japan), AMED, and SECOM Science and Technology Foundation.

Conflict of Interest Disclosure:
Some authors received grants or advisory roles from pharmaceutical and technology companies. Full disclosures are available in the published article.