African swine fever not recently imported to Europe, has been around for years

A new study in Genome Biology and Evolution, published by Oxford University Press, finds that the African Swine Fever virus, currently circulating in Europe, is not the result of a recent introduction. Instead, the virus has been present in the region since 2007. Its current dramatic spread appears to be driven largely by people within Europe traveling longer distances.

African Swine Fever virus is a highly virulent DNA virus that causes a severe hemorrhagic disease of the same name affecting both domestic pigs and wild boars. The disease is characterized by high mortality rates, leading to significant economic losses in the pork industry. According to estimates from the Food and Agriculture Organization, the virus has led to approximately $2.1 billion in direct economic losses over the past 17 years. Additionally, the outbreak has destroyed many small and medium-sized farms, contributing to structural transformations in agricultural markets, notably in China. Currently, there is no vaccine against the virus available widely.

Initially limited to the sub-Saharan African region, the virus (specifically genotype II) spread globally and is now a major concern in Africa, Europe, Asia, the Pacific and, more recently, the Caribbean. In 2024, the World Organization for Animal Health reported African Swine Fever virus outbreaks in seven European countries, with over one million pigs lost since 2022.

The researchers here analyzed ten samples from domestic pigs and wild boar, collected between July 26, 2016, and August 23, 2019, as part of the State Food and Veterinary Service of the Republic of Lithuania surveillance activities in Lithuania. From these samples, they generated complete genome sequences of African Swine Fever Virus. Researchers used these new sequences to expand the existing dataset of African Swine Fever Virus genomes genotype II and study of the spread of the virus across the European continent.

The analysis shows the African Swine Fever Virus genotype II now circulating in Europe shares a single common ancestor with those circulating in Africa, with no evidence of recent viral exchanges between the two continents. Sequences from Europe are closely related to each other and some countries, particularly Poland, Lithuania, Ukraine, and Germany, appear to have played important roles in the regional spread of the virus across the continent.

“African swine fever virus continues to threaten domestic pig and wild boar populations in Europe," said the paper’s lead author, Christopher Netherton. “Each viral genome we sequence helps to deepen our understanding of the virus’s circulation dynamics.”

The paper, “Exploiting viral DNA genomes to explore the dispersal history of African swine fever genotype II lineages in Europe,” is available (at midnight on June 3^rd) at https://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evaf102.

Direct correspondence to: 
Christopher L. Netherton
The Pirbright Institute
Ash Road
Pirbright, Woking. UNITED KINGDOM
christopher.netherton@pirbright.ac.uk

To request a copy of the study, please contact:
Daniel Luzer 
daniel.luzer@oup.com