Acta Pharmaceutica Sinica B Volume 15, Issue 6 Publishes

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/6

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

 

Editorial Special Column: Nanomedicines for tumor microenvironment modulation by Huile Gao, Feihu Wang and Yang Shi, (https://doi.org/10.1016/j.apsb.2025.05.027). Nanomedicine is a powerful tool for disease microenvironment modulation and disease treatment. Deep understanding of the function of microenvironment in disease development may provide new targets for nanomedicine design and disease treatment.

 

Nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy by Chenwei Jiang, Minglu Tang, Yun Su and colleagues, (https://doi.org/10.1016/j.apsb.2025.04.002). Glucose metabolism modulating nanomedicines (GMMNs) precisely target tumor cells, respond to the tumor microenvironment, enable multi-drug co-delivery, and facilitate combination therapies, thereby effectively correcting aberrant glucose metabolism, reshaping the immunosuppressive microenvironment, and ultimately improving the efficacy of cancer immunotherapy.

 

Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma by Fu Wang, Haoyu You, Huahua Liu and colleagues, (https://doi.org/10.1016/j.apsb.2025.03.015). Glucose metabolism modulating nanomedicines (GMMNs) precisely target tumor cells, respond to the tumor microenvironment, enable multi-drug co-delivery, and facilitate combination therapies, thereby effectively correcting aberrant glucose metabolism, reshaping the immunosuppressive microenvironment, and ultimately improving the efficacy of cancer immunotherapy.

 

Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions by Kishore Madamanchi, Jianhua Zhang and Girish C. Melkani, (https://doi.org/10.1016/j.apsb.2025.04.011). Circadian rhythm disruption (CRD) accelerates aging, neurodegeneration, and gut dysbiosis, creating a feedback loop that worsens Alzheimer's disease (AD). AD further disrupts circadian rhythms, fueling cognitive decline and metabolic imbalance. Time-restricted feeding (TRF) realigns circadian rhythms, restores gut microbiome balance, and enhances cognitive function, offering a non-invasive strategy to slow AD progression.

 

Other articles include:

 

Special Column: Nanomedicines for Tumor Microenvironment Modulation

Reviews

Advancements in CRISPR/Cas systems for disease treatment

Yangsong Xu, Hao Le, Qinjie Wu, Ning Wang, Changyang Gong

 

Original articles

Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases

Qiu Wang, Bin Wan, Yao Feng, Zimeng Yang, ... Qikun Jiang

 

Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy

Yanyan Xu, Xiangtong Ye, Yanfeng Du, Wenqin Yang, ... Weiwei Zhang

 

Submicron-sized superantigen biomimetic liposomes with highly efficient pulmonary accumulation to remodel local immune microenvironment for cancer chemoimmunotherapy

Bochuan Yuan, Feng Zhang, Qiucheng Yan, Wanmei Wang, ... Fei Xie

 

Reviews

Obesity–cancer axis crosstalk: Molecular insights and therapeutic approaches

Ahmed Rakib, Md Abdullah Al Mamun, Mousumi Mandal, Priti Sinha, Udai P. Singh

 

Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease

Zihan Wang, Kaige Zhang, Minghao Huang, Dehao Shang, ... Xinwen Zhang

 

Unravelling the target landscape of tranylcypromines for new drug discovery

Yihui Song, Junbiao Chang, Bin Yu

 

Tools

Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia

Jingyu Wang, Xiangning Liu, Rongxin Zhu, Ying Sun, ... Wei Wang

 

 

 

 

 

Original articles

Neurokinin 1 receptor inhibition alleviated mitochondrial dysfunction via restoring purine nucleotide cycle disorder driven by substance P in acute pancreatitis

Chenxia Han, Lu Li, Lin Bai, Yaling Wu, ... Qing Xia

 

SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts

Tongzhu Jin, Huiying Gao, Yuquan Wang, Zhiwei Ning, ... Haihai Liang

 

RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis

Wen Zhang, Yulin Peng, Meirong Zhou, Lei Qian, ... Xiaochi Ma

 

An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation

Xinxing Li, Wenxin Ding, Yan Lu, Haiyan Zhu, ... Daofeng Chen

 

ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells

Yuhua Deng, Zhiyan Chen, Peixian Chen, Yaming Xiong, ... Dan Zhou

 

Ablation of macrophage transcriptional factor FoxO1 protects against ischemia–reperfusion injury-induced acute kidney injury

Yao He, Xue Yang, Chenyu Zhang, Min Deng, ... Lu Tie

 

The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition

Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, ... Chaofeng Zhang

 

Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis

Bin Liu, Wen-Zhe Deng, Wen-Hua Hu, Rong-Xi Lu, ... Rong-Rong He

 

Design, synthesis and biological evaluation of a novel class of indazole-containing compounds with potent anti-influenza activities targeting the PA-PB1 interface

Yun-Sang Tang, Chao Zhang, Jing Xu, Haibo Zhang, ... Pang-Chui Shaw

 

Discovery of papyifuran A as an unusual cembrane diterpenoid from Boswellia papyrifera resin reveals EEF2 as a potent new drug target for fibrosis of multiple organs

Madhu Babu Sura, Yeting Zhou, Jijun Li, Yongxian Cheng

 

Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope

Hong Xuan, Siqi Bian, Qinguo Liu, Jun Li, ... Liqin Zhang

 

Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking

Haodong Zhu, Xupeng Tong, Qi Wang, Aijing Li, ... Zhihong Yao

 

Targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by biomimetic codelivery

Siqi Wu, Qing Tang, Weifeng Fang, Zhe Sun, ... Yongzhuo Huang

 

A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy

Haitao Yuan, Xiaoxian Wang, Xin Sun, Di Gu, ... Zhijie Li

 

Alginate lyase immobilized Chlamydomonas algae microrobots: minimally invasive therapy for biofilm penetration and eradication

Xiaoting Zhang, Huaan Li, Lu Liu, Yanzhen Song, ... Yingfeng Tu

 

A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment

Rui Liao, Yuequan Wang, Ziqi Lin, Yuting Wang, ... Cong Luo

 

Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system

Jizhuang Ma, Keda Zhang, Wenhan Li, Yu Ding, ... Pingtian Ding

 

Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux

Yizhou Wu, Hongyan Zhou, Hao Liu, Jiayao Hu, ... Bin Liu

 

Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines

Jing-Jing Chen, Ting Gong, Wei-Bo Wang, Tian-Jiao Chen, ... Ping Zhu

 

Letter to the Editor

Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota

Manjiong Wang, Xiaobo Guo, Hanfang Liu, Xiao Li, ... Yixiang Xu

 

Highlights

PRIME, a temperature-guided language model revolutionizes protein engineering

Yuanxi Yu, Qianhui Wang, Yike Zou

 

Mechanism of Alzheimer's disease treatment by sound and light stimulation

Lixuan Ren, Xiwen Ma, Jianping Ye

 

Editorial

Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy

Fan Jia, Siyuan Peng, Wenhao Wang, Xin Pan

 

Commentary

Unlocking the therapeutic potential of RNA splicing in lung fibrosis: Insights from the SRSF7–PKM axis

Bi-Sen Ding

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 24.3

Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy) 

JIF without self-citation: 13.8

 

ISSN 2211-3835

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