Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei
image: Phase separation in chromatin assembly of the nuclei and the assembly of mitochondrial nucleoid. The schematic diagram represents the phase separation in chromatin condensation and nucleus architecture. The phase separation of TFAM (red) and DNA (gray) drives the nucleoid assembly in mitochondria
Credit: Qi Long, Yanshuang Zhou, Jingyi Guo, Hao Wu, Xingguo Liu
In mammalian cells, besides nuclei, mitochondria are the only semi-autonomous organelles possessing own DNA organized in the form of nucleoids. While eukaryotic nuclear DNA compaction, chromatin compartmentalization and transcription are regulated by phase separation, their recent work proposed a model of mitochondrial nucleoid self-assembly and transcriptional regulation by multi-phase separation. Herein, they summarized the phase separation both in the nucleus and mitochondrial nucleoids, and did a comparison of the organization and activity regulating, which would provide new insight into the understanding of both architecture and genetics of nucleus and mitochondrial nucleoids.
The work entitled “Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei”was published on Biophysics Reports (published on Jun. 2023).