Smart bandage with “plant power” heals chronic wounds faster than market leaders, Chinese-German team reports

A multidisciplinary team from Nanjing Forestry University, Nanjing Medical University and the University of Bayreuth has unveiled a next-generation wound dressing that behaves like a living leaf yet fights like a miniature pharmacy. Described today in the Journal of Bioresources and Bioproducts, the “dual-network gel” (DNG) bandage combines neomycin-grafted cellulose nonwovens with a polyvinyl alcohol/cellulose-nanofiber aerogel that is dyed with blueberry anthocyanins.

When the dressing contacts wound fluid its color shifts from pink to brown, providing an instant visual alert if pH rises above 8—a hallmark of bacterial infection. Simultaneously, the aerogel swells into a hydrogel, generating a gentle negative pressure of –1.44 mmHg that continuously draws out exudate without external pumps. Laboratory assays show the material eliminates more than 99.99 % of Staphylococcus aureus and Escherichia coli within 30 minutes and maintains this potency for at least 180 days of shelf storage.

In a mouse model of S. aureus-infected full-thickness wounds, animals treated with the DNG bandage achieved 88 % wound closure after seven days, outperforming a leading commercial dressing that closed 80 %. Histology revealed denser new blood vessels and hair follicles beneath the experimental dressing, while real-time PCR showed sharply lower levels of the inflammatory markers TNF-α and IL-1β. Despite its aggressive antimicrobial action, the dressing exhibited minimal cytotoxicity and hemolysis below 3 %, and it fully biodegraded in soil within 90 days.

Lead authors Hao Wu and Chao Deng say the innovation marries infection control, exudate management and smart monitoring in a single, low-cost platform that could be scaled for chronic diabetic ulcers and battlefield injuries alike.

See the article:

DOI

https://doi.org/10.1016/j.jobab.2025.06.001.

Original Source URL

https://www.sciencedirect.com/science/article/pii/S2369969825000386

Journal

Journal of Bioresources and Bioproducts