DALLAS, Aug. 11, 2025 — Cardiovascular disease is the No. 1 killer of women, according to the American Heart Association, claiming more lives each year than all forms of cancer combined. The American Heart Association, a relentless force changing the future of health for everyone everywhere, is working to change that through its continued investments in groundbreaking science, community programs and targeted initiatives which aim to close the gaps in awareness, diagnosis and treatment for women’s heart health.
That work will get a powerful boost through a transformational $3 million gift from longtime American Heart Association volunteer leaders and philanthropists Lee and Valerie Shapiro, of Chicago. This investment will help sustain the Association’s Mother’s Day matching gift campaign for years to come while also providing critical support to the Go Red for Women® Venture Fund, fueling innovation and advancing research in women’s heart health.
The Shapiros’ connection to the American Heart Association is deeply personal. Both lost parents to cardiovascular disease — yet Valerie’s mother lived an additional two decades thanks to advances in treatment supported by the Association. That profound gift of time inspired the couple to help ensure more families have the opportunity to share moments with the women they love.
In 2021, Lee and Valerie helped launch the Millions Honoring Moms campaign, matching every online gift made during May, the month of Mother’s Day, up to $1 million. Heart Association research shows that fewer than half of women recognize heart disease as their greatest health threat, and women — particularly women of color — continue to be underrepresented in cardiovascular research. The Millions Honoring Moms campaign helps combat that by investing in research, prevention and education. The campaign helps further spread awareness around women’s health through a variety of media channels, such as social media, email, and television. The effort has grown into a national movement, inspiring thousands to give in tribute to all mothers and cherished women in their lives. The Shapiros’ leadership as both dedicated volunteers and foundational supporters has amplified the campaign’s reach and inspired others to give.
“The Shapiros’ generosity is nothing short of extraordinary and will support the Association’s work to change the future of health,” said Nancy Brown, chief executive officer of the American Heart Association. “Their commitment has already touched thousands of lives, and this new gift will drive even greater impact for years to come. We are deeply grateful for their vision, leadership and unwavering dedication to our mission.”
With their new $3 million gift, the Shapiros will continue their matching gift commitment for multiple future Millions Honoring Moms campaigns, ensuring that every dollar donated in honor of mothers and other meaningful women will continue to be multiplied. The gift will also advance the Go Red for Women Venture Fund, which invests in innovative solutions and community-based initiatives to improve outcomes for women’s cardiovascular health.
“Having spent the last 25-plus years investing in innovation for better health, we have learned how important it is to nurture early-stage founders who are passionate about improving lives,” said Lee Shapiro, venture capitalist and managing partner at 7wireVentures. “We are proud to support the Go Red for Women Venture Fund and their mission of advancing women’s health at every age, stage and season of life.”
Lee Shapiro currently serves as volunteer chairperson of the American Heart Association’s Board of Directors and has held multiple leadership roles over the years, including treasurer and chair-elect. Valerie has been an equally passionate partner in the mission, co-leading the Chicago Heart Ball to record-breaking success. Together, they have championed women’s heart health locally and nationally, inspiring countless others to join the fight against cardiovascular disease.
Additional Resources:
- American Heart Association announces new volunteer leaders for 2025-26
- New AHA board chairperson driven to improve health care
- Gender gaps in cardiovascular disease diagnosis and treatment persist; $28 billion opportunity found
- Startups chosen to drive technology-driven improvements in women’s heart and brain health
- $1 million matching gift honors moms, boosts heart health
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About the American Heart Association
The American Heart Association is a relentless force for a world of longer, healthier lives. Dedicated to ensuring equitable health in all communities, the organization has been a leading source of health information for more than one hundred years. Supported by more than 35 million volunteers globally, we fund groundbreaking research, advocate for the public’s health, and provide critical resources to save and improve lives affected by cardiovascular disease and stroke. By driving breakthroughs and implementing proven solutions in science, policy, and care, we work tirelessly to advance health and transform lives every day. Connect with us on heart.org, Facebook, X or by calling 1-800-AHA-USA1.
About American Heart Association Ventures®
American Heart Association Ventures leads and coordinates the venture capital programs of the American Heart Association, bridging the funding gap between research and real-world impact across the landscape of cardiovascular and brain health. We invest in companies working to translate evidence-based science, research and clinical know-how into commercially actionable and sustainable products and services. Through multiple investment models, we fund companies that amplify the American Heart Association’s mission to advance health and hope for everyone, everywhere. Connect with us on heart.org/ventures and LinkedIn.
About Go Red for Women®
The American Heart Association’s signature initiative, Go Red for Women®, is a comprehensive platform designed to increase women’s heart health awareness and serve as a catalyst for change to improve the lives of women globally. While the majority of cardiac events can be prevented, cardiovascular disease is the leading cause of death in women, claiming the lives of 1 in 3 women. For more than two decades, Go Red for Women has encouraged awareness. The movement harnesses the energy, passion and power of women to band together and collectively wipe out heart disease. It challenges them to know their risk for heart disease and take action to reduce their personal risk. It also gives them tools they need to lead a heart healthy life. The Go Red for Women movement is nationally sponsored by CVS Health, with additional support from national cause supporters. For more information, please visit GoRedforWomen.org or call 1-800-AHA-USA1 (242-8721).