A review illuminates the complex mechanisms and management strategies for sensitive skin syndrome
image: The key factors and the main underlying pathophysiological mechanisms contributing to sensitive skin was displayed.
Credit: “Guangdong Marubi Biotechnology Co., Ltd., China” "Guangzhou Marumed Research Co., Ltd., China"
Sensitive skin affects up to 70 % of women and 60 % of men worldwide, yet it remains a subjective complaint lacking consensus definition.
Key Research Breakthroughs Detailed in the Review:
1. Neurovascular Hyperreactivity Mechanism: The article establishes that abnormal activation of transient receptor potential (TRP) channels, particularly TRPV1 and TRPA1, in cutaneous sensory nerve endings serves as the primary pathway for SSS symptoms. This neural hypersensitivity explains the characteristic burning, stinging, and itching sensations without visible clinical signs.
2. Skin Barrier Dysfunction Analysis: Contrary to previous assumptions, the review demonstrates that barrier impairment in SSS involves specific defects in tight junction proteins and abnormal keratinocyte differentiation rather than generalized barrier failure.
3. Inflammatory Cascade Mapping: The authors detail how neurogenic inflammation, mediated by substance P and calcitonin gene-related peptide (CGRP), creates a self-perpetuating cycle of inflammation and sensory amplification.
4. Advanced Assessment Paradigms: The review introduces innovative quantitative evaluation methods including neurosensory testing, biophysical measurement combinations, and novel provocative tests that enable objective SSS diagnosis and severity grading.
"The elucidation of TRP channel pathophysiology in sensitive skin represents a paradigm shift in our understanding of this condition," stated the lead author. "This mechanistic clarity enables the development of precisely targeted interventions that address the root causes rather than merely alleviating symptoms. We are now equipped to create truly effective solutions based on solid scientific evidence."