image: Representative Wide-Field acquisition of PV interneurons calcium signals before the ischemic lesion, 2 days post-stroke (acute damage) and 42 days post-stroke after 5 weeks of combined rehabilitation with robotic therapy and 40 Hz TACs and 1 week of follow-up. The bright area in the second image locates the ischemic damage.
Credit: Vignozzi L, et al., 2025, PLOS Biology, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model
In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: https://plos.io/4gUkAy5
Article title: Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice
Author countries: Italy, Switzerland
Funding: The study was funded by: Regione Toscana, PERSONA project, bando Salute 2018, https://www.regione.toscana.it/-/bando-ricerca-salute-2018, SM; H2020 EXCELLENT SCIENCE-European Research Council (ERC) under grant agreement 692943, https://cordis.europa.eu/programme/id/H2020-EU.1.1., MC; Regione Toscana, NIMBLE project (20RSVP), bando Salute 2018, https://www.regione.toscana.it/-/bando-ricerca-salute-2018, (ALAM); THE Tuscany Health Ecosystem ECS_00000017 MUR_ PNRR, https://www.mur.gov.it/it/pnrr/missione-istruzione-e-ricerca, ALAM; Grant Fondazione Baroni 2021, https://fondazionebaroni.it/bandi/, CS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Journal
PLOS Biology
Method of Research
Experimental study
Subject of Research
Animals
COI Statement
Competing interests: The authors have declared that no competing interests exist.