Features of the monocyte inflammatory response in patients with premature coronary artery disease
image: ROC analysis of multivariate logistic regression model. Curves are presented for each of the indicators included in the model separately and for the entire model (predicted probability of having premature CAD)
Credit: 1)Tatiana Blokhina, Tatiana Kirichenko, Yuliya Markina, Ulyana Khovantseva, Ivan Melnikov, Olga Guseva, Sergey Bazanovich, Sergey Kozlov, Alexander Orekhov
Key Findings:
Researchers found that monocytes from patients with premature CAD secreted higher levels of pro-inflammatory cytokines compared to healthy individuals. These cytokines, including TNF-α, IL-1β, and MCP-1, are known to contribute to the development and progression of atherosclerosis, the underlying cause of CAD.
Significance:
The study suggests that monocyte inflammation plays a crucial role in the early development of CAD. Identifying individuals with increased monocyte inflammatory activity could help predict and prevent CAD in young patients who may not have traditional risk factors.
The work entitled “Features of the monocyte inflammatory response in patients with premature coronary artery disease”was published on Biophysics Reports (published on Feb, 2025).