Reston, VA (December 5, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
Summaries of the newly published research articles are provided below.
How New PET/CT Imaging Shapes Prostate Cancer Staging
This study explored whether a newer scan, 18F-PSMA-1007 PET/CT, offers more accurate staging of intermediate- and high-risk prostate cancer than traditional 18F-NaF PET/CT. Researchers assessed how each method detected lymph node or bone spread and how differences in imaging could shift disease stage and influence treatment plans.
Comparing New PET/MRI Imaging to mpMRI for Detecting Prostate Cancer
Researchers reviewed whether 18F-flotufolastat PET/MRI can more accurately spot significant prostate cancer than traditional mpMRI. By comparing each scan’s scoring system with biopsy results, the study examined detection performance in both whole patients and specific prostate regions to see which method identifies disease more reliably.
Evaluating PRRT for Rare Adrenal Tumors
This study reviewed outcomes of patients with metastatic pheochromocytoma and paraganglioma treated with peptide receptor radionuclide therapy (PRRT). Researchers assessed tumor response, symptom relief, blood pressure changes, and treatment-related side effects over long-term follow-up to understand how well this therapy performs in real-world clinical practice for patients facing these rare cancers.
A New Approach to Sharper Whole-Body PET Imaging
This study introduces AWSM-PET, a prototype system that adds two high-resolution detector panels to a clinical PET/CT scanner. Researchers detail its design and test performance using phantoms and early human scans, showing higher sensitivity and clearer visualization of very small structures during whole-body imaging.
Tracking Early Heart Uptake to Improve ATTR-CM Imaging
Researchers measured how quickly a common radiotracer accumulates in the heart, blood, and bone in people with and without transthyretin amyloid cardiomyopathy. Using dynamic SPECT/CT at multiple time points, the team mapped uptake patterns and assessed whether early imaging could reliably match standard late-phase scans.
How PSMA PET May Improve Planning for HIFU in Prostate Cancer
A cohort of patients receiving focused ultrasound therapy for prostate cancer was evaluated to see how pre-treatment PSMA PET influences outcomes. The study compared PET with mpMRI for identifying biopsy-proven lesions, assessed recurrence and failure-free survival, and explored whether PET offers clearer guidance for treatment planning.
Exploring a New GRPR-Targeted Therapy for Advanced Solid Tumors
A first-in-human trial evaluated 177Lu-NeoB, a GRPR-targeted radiotherapy for patients with advanced solid tumors confirmed to express the receptor. Phase 1 explored safe dosing, monitored toxicities, and measured organ radiation exposure to determine an appropriate dose for further clinical testing.
Using FES PET/CT to Predict Endocrine Therapy Response in Metastatic Breast Cancer
A meta-analysis of FES PET/CT studies examined how functional estrogen receptor activity relates to treatment outcomes. By comparing lesion uptake levels and heterogeneity across patients, the analysis evaluated whether imaging-based measures can help forecast endocrine therapy response and progression-free survival.
Visualizing VEGF Activity in Macular Degeneration with Fluorescent Imaging
A pilot trial tested whether fluorescently labeled bevacizumab could safely highlight VEGF activity in patients with neovascular age-related macular degeneration. Using a commercial imaging system, the team evaluated two doses and monitored fluorescence over several days to assess tracer uptake in retinal vessels and the macula.
Evaluating FAPI PET/CT for Detecting Hidden Peritoneal Spread in Gastric Cancer
A prospective cohort of patients with locally advanced gastric cancer underwent FAPI PET/CT before laparoscopic staging to assess its ability to detect occult peritoneal metastasis. The study measured changes in treatment intent, diagnostic accuracy, and cost, and compared the imaging approach with standard surgical staging.
Using PSMA PET Metrics to Anticipate Toxicity and Quality-of-Life Outcomes in mCRPC
A retrospective analysis examined whether baseline quantitative features from PSMA PET can forecast hematologic toxicity and patient-reported outcomes in men receiving 177Lu-PSMA-617. By linking imaging metrics with clinical events and quality-of-life measures, the study explored how PET-based parameters may help guide treatment expectations.
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About JNM and the Society of Nuclear Medicine and Molecular Imaging
The Journal of Nuclear Medicine (JNM) is the world’s leading nuclear medicine, molecular imaging and theranostics journal, accessed 15 million times each year by practitioners around the globe, providing them with the information they need to advance this rapidly expanding field. Current and past issues of The Journal of Nuclear Medicine can be found online at http://jnm.snmjournals.org.
JNM is published by the Society of Nuclear Medicine and Molecular Imaging (SNMMI), an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes. For more information, visit www.snmmi.org.
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Journal of Nuclear Medicine