About The Study: In this cohort study, exposure to adverse experiences throughout life was associated with increased risks of dementia and stroke, with depression mediating these associations. These findings highlight the importance of implementing life-course interventions that address both psychological trauma and mental health to reduce the burden of neurovascular diseases.
Corresponding Authors: To contact the corresponding authors, email Jianhui Zhao, MPH, PhD, (jzhao40@mgh.harvard.edu) and Shan Liu, PhD, (graystar92@163.com).
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(doi:10.1001/jamanetworkopen.2025.56012)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
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