Multimedia Release

Unlocking the cell's 'gatekeeper': UC Irvine researchers discover critical RNA quality-control factor, LENG8

Peer-Reviewed Publication

University of California - Irvine

Professor Yongsheng Shi

image: 

Yongsheng Shi, PhD, and Lusong Tian, PhD from the UC Irvine School of Medicine 

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Credit: UC Irvine School of Medicine

Journal

Molecular Cell

DOI

10.1016/j.molcel.2026.02.023

Subject of Research

Cells

Article Title

LENG8 mediates RNA nuclear retention and degradation in eukaryotes

Article Publication Date

19-Mar-2026

COI Statement

This work was supported by the National Institutes of Health under awards R35GM149294, R01CA297834, DP2GM149554; a Hewitt Foundation Postdoctoral Fellowship; and the Washington Research Foundation Postdoctoral Fellowship. Additional support was provided by UCI core facilities funded by P30CA062203, CA-62203, and NIH-S10OD032327-01.

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