Increased impact of GPIb receptors on platelet adhesion under flow in severe COVID-19
image: Platelet adhesion and its inhibition by anti-GPIb mAb. A,B Platelet adhesion for ICU COVID-19 patients (n = 17) and healthy controls (n = 17), with and without addition of mAb blocking GPIb. Wilcoxon matched-pairs signed-rank test p < 0.0001. C Inhibition of platelet adhesion by anti-GPIb antibody calculated as percent of adhesion in experiments without addition of inhibitor.
Credit: HIGHER EDUCATION PRESS
This study demonstrates that the contribution of GPIb to platelet adhesion was significantly altered in patients with severe COVID-19. Further investigations are necessary to determine the pathogenic mechanisms that produced this change.
The work entitled “Increased impact of GPIb receptors on platelet adhesion under flow in severe COVID-19”was published in Biophysics Reports (ahead of print in Apr. 2026).