About The Study: In patients presenting to endovascular treatment (EVT)-capable centers 4.5 to 24 hours after stroke onset with proximal middle cerebral artery occlusion, intravenous tenecteplase before EVT did not improve clinical outcomes vs EVT alone.
Corresponding Authors: To contact the corresponding authors, email Yongjun Wang, MD, (yongjunwang@ncrcnd.org.cn) and Yunyun Xiong, MD, PhD, (xiongyunyun@bjtth.org).
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(doi:10.1001/jama.2026.4292)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the European Stroke Organisation Conference.
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Journal
JAMA