image: Florian Weinberger
Credit: CNIC
The European Research Council (ERC) has awarded an Advanced Grant to CNIC researcher Florian Weinberger for the project CARDIOSWITCH, which aims to uncover how the mechanical activity of heart muscle cells shapes cardiac biology and to develop new regenerative strategies for congenital heart disease.
The five-year project will receive up to €2.5 million in funding through the ERC Advanced Grant programme, one of Europe’s most prestigious and competitive research funding schemes.
CARDIOSWITCH will develop innovative tools to reversibly control the activity of cardiomyocytes—the cells responsible for heart contraction—with unprecedented precision. By combining stem cell-derived cardiac models, human cardiac tissue and preclinical models, the project will investigate how mechanical workload influences cardiomyocyte proliferation, organisation, and function.
A major objective of the project is to determine how many actively contracting cardiomyocytes are required to restore heart function, a key question for the development of regenerative therapies. CARDIOSWITCH will also test new approaches to improve the transplantation of stem cell-derived cardiomyocytes and reduce the risk of ventricular arrhythmias, one of the main barriers to their clinical application.
Dr. Weinberger said: “A distinctive aspect of CARDIOSWITCH is its focus on congenital heart disease. While most cardiac regeneration research has concentrated on adult patients with coronary artery disease, this project targets a patient population that may be particularly well suited to benefit from regenerative approaches: children with congenital heart defects”.
Despite major advances in surgery and clinical care, therapeutic options capable of restoring damaged or underdeveloped heart muscle in these patients remain extremely limited. By understanding how mechanical activity regulates cardiomyocyte biology and regeneration, CARDIOSWITCH aims to pave the way for innovative therapies specifically tailored to the needs of children with congenital heart disease.
Florian Weinberger said: “Understanding how the rhythmic contraction of heart muscle cells regulates cardiac biology could unlock entirely new opportunities for regeneration, especially for children, for whom effective treatment options remain limited.”
The project builds on Weinberger’s expertise in cardiac tissue engineering, optogenetics, chemogenetics and preclinical models of congenital heart disease. Ultimately, CARDIOSWITCH aims to establish a foundation for regenerative therapies capable of restoring coordinated heart function in children with severe congenital heart defects.
Florian Weinberger conducts his research within the Regeneration Program at the CNIC.
The ERC Advanced Grants support outstanding senior researchers pursuing ambitious, curiosity-driven projects with the potential to lead to major scientific breakthroughs. In the 2025 competition, the ERC awarded €838 million to 319 researchers across Europe. The grants are funded through the European Union’s Horizon Europe programme.