About the Study: This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers. In a cohort of about 1.18 million patients with nonmetastatic prostate cancer, about half of focal therapy procedures occurred in low-, high-, or very-high-risk disease, settings in which routine use is not supported by current guidelines. Overall use remained uncommon.
Corresponding Author: Quoc-Dien Trinh, MD, MBA, Department of Urology, University of Pittsburgh School of Medicine, 5200 Centre Ave, Pittsburgh, PA 15232 (trinhq@upmc.edu).
10.1001/jama.2026.12411
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