image: Skull TSPO PET signal is higher in individuals with chronic pain than in healthy controls. Average [11C]PBR28 PET signal, which measures TSPO levels, in individuals with chronic pain (N=125; left) and healthy controls (N=22; right).
Credit: Marco Loggia/Mass General Brigham
Journal
Science Translational Medicine
Method of Research
Imaging analysis
Subject of Research
People
Article Title
Elevated translocator protein in skull bone marrow is linked to human chronic pain
Article Publication Date
2-Sep-2026
COI Statement
Loggia has consulted for Ono Pharma INC and Sensorium Therapeutics. Loggia and Gilman received a research grant from Jazz Pharmaceuticals. Napadow is a paid consultant for Cala Health. Loggia, Mohammadian, Brusaferri and Gilman are named inventors on a pending, unpublished Patent Cooperation Treaty (PCT) application. This application relates to aspects of the work described in this manuscript and is currently considered confidential. The authors are not aware of any material transfer agreements, issued patents, or third-party pending patent applications that would restrict readers’ or researchers’ non-commercial research use of the methods, techniques, materials, or findings described in this article. Any rights associated with the pending application are not intended to restrict research use, but commercial use may be subject to applicable patent rights if such rights issue.