Article Highlight | 8-Sep-2026

Cover article collection released by Synthetic and Systems Biotechnology

KeAi Communications Co., Ltd.

As an open-access, peer-reviewed journal dedicated to advancing synthetic and systems biology, Synthetic and Systems Biotechnology (SSB) provides a premier platform for publishing cutting-edge research in metabolic engineering, genome editing, and biomanufacturing. We are pleased to present a curated collection of our recent cover articles, featuring breakthroughs ranging from enzyme–chemical interaction prediction, genome-scale modeling and novel biosensor development to metabolic engineering of industrially relevant microbial hosts and next-generation gene-editing tools. These studies highlight the field's rapid evolution from fundamental tool discovery to translational industrial applications.

All articles are freely available for download. We invite you to explore these featured works and hope they inspire new ideas and collaborations.

1. Descriptor-augmented machine learning for enzyme-chemical interaction predictions

2. A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis

3. Auxotrophy-based curation improves the consensus genome-scale metabolic model of yeast

4. Engineering artificial cross-species promoters with different transcriptional strengths

5. Metabolic engineering of Glarea lozoyensis for high-level production of pneumocandin B0

6. T7 RNA polymerase-guided base editor for accelerated continuous evolution in Bacillus subtilis

7. Metabolic engineering of Escherichia coli for squalene overproduction

8. CRISPy-web 3.0: A unified platform for multi-modal guide RNA design for CRISPR and TnpB genome editing applications

9. Truncation of LPD1 promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast

10. Formate-driven efficient pyruvate biosynthesis in Vibrio natriegens

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Contact the author:

Senior Publisher: Wei Yan, wei.yan@keaipublishing.com

The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 200 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).

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