News Release

Impaired sleep linked to lower pain tolerance

Peer-Reviewed Publication

Wolters Kluwer Health

April 30, 2015 - People with insomnia and other sleep problems have increased sensitivity to pain, reports a study published in PAIN®, the official publication of the International Association for the Study of Pain. The journal is published by Wolters Kluwer.

The effect on pain tolerance appears strongest in people who suffer from both insomnia and chronic pain, who may benefit from treatments targeting both conditions. The study was led by Børge Sivertsen, PhD, of the Norwegian Institute of Public Health, Bergen.

People with Insomnia Have Increased Pain Sensitivity

The study included more than 10,400 adults from a large, ongoing Norwegian health study. Each subject underwent a standard test of pain sensitivity--the cold pressor test--in which subjects are asked to keep their hand submerged in a cold water bath.

Subjects were asked about various types of sleep impairment, including insomnia, total sleep time, and sleep latency (time to falling asleep), and researchers assessed the relationships between measures of sleep impairment and pain sensitivity. The study also looked at other factors potentially affecting sleep impairment and pain perception, including chronic (persistent or recurring) pain and psychological distress (such as depression and anxiety).

Overall, 32 percent of participants were able to keep their hand in the cold water throughout the 106-second test. Participants with insomnia were more likely to take their hand out early: 42 percent did so, compared with 31 percent of those without insomnia.

Pain sensitivity increased with both the frequency and severity of insomnia. For example, compared with individuals who reported no insomnia, rates of reduced pain tolerance were 52 percent higher for subjects reporting insomnia more than once weekly versus 24 percent for those with insomnia once monthly.

Pain sensitivity was also linked to sleep latency, although not to total sleep time. The relationships were unchanged after adjustment for age and sex. The effect was smaller, but still significant, after further adjustment for psychological distress.

Synergistic Effect of Sleep Problems and Chronic Pain

There was also strong joint (synergistic) effect of insomnia and chronic pain on pain tolerance. Patients reporting high problems with both insomnia and chronic pain were more than twice as likely to have reduced tolerance to pain.

Many patients who experience sleep impairment and pain face high costs and personal difficulties. "While there is clearly a strong relationship between pain and sleep, such that insomnia increases both the likelihood and severity of clinical pain," Dr. Sivertsen and coauthors write, "it is not clear exactly why this is the case."

The new study is the first to link insomnia and impaired sleep to reduced pain tolerance in a large, general population sample. The results suggest that psychological factors may contribute to the relationship between sleep problems and pain, but they do not fully explain it. More research is needed to explore the role of neurotransmitters, such as dopamine, that may affect both pain and sleep.

Meanwhile, the study clearly shows the need for efforts to improve sleep among patients with chronic pain and vice versa. Cognitive-behavioral therapy approaches have proved effective for pain problems and insomnia individually. Dr. Sivertsen and colleagues call for studies evaluating earlier interventions targeting patients who are simultaneously affected by both problems.

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Click here to read "Sleep and Pain Sensitivity in Adults."

Article: "Sleep and Pain Sensitivity in Adults." (doi: 10.1097/j.pain.0000000000000131)

About PAIN

PAIN is IASP's official journal. Published monthly, PAIN presents original research on the nature, mechanisms, and treatment of pain. Available to IASP members as a membership benefit, this peer-reviewed journal provides a forum for the dissemination of multidisciplinary research in the basic and clinical sciences. It is cited in Current Contents and Index Medicus.

About the International Association for the Study of Pain

IASP is the leading professional forum for science, practice, and education in the field of pain. Membership is open to all professionals involved in research, diagnosis, or treatment of pain. IASP has more than 7,000 members in 133 countries, 94 national chapters, and 20 special interest groups (SIGs). IASP brings together scientists, clinicians, health-care providers, and policymakers to stimulate and support the study of pain and to translate that knowledge into improved pain relief worldwide.

About Wolters Kluwer

Wolters Kluwer is a global leader in professional information services. Professionals in the areas of legal, business, tax, accounting, finance, audit, risk, compliance and healthcare rely on Wolters Kluwer's market leading information-enabled tools and software solutions to manage their business efficiently, deliver results to their clients, and succeed in an ever more dynamic world.

Wolters Kluwer reported 2014 annual revenues of €3.7 billion. The group serves customers in over 170 countries, and employs over 19,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands. Wolters Kluwer shares are listed on NYSE Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices. Wolters Kluwer has a sponsored Level 1 American Depositary Receipt program. The ADRs are traded on the over-the-counter market in the U.S. (WTKWY).

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