Scientists have - for the first time - shown how chemical triggers in the nervous system can amplify the pain experienced by mammals in response to certain stimuli.
The pain system probably evolved to alert them to life-threatening dangers. As they approach objects that are extremely hot or cold or are biting them, they experience intense pain - allowing them to get out of harm's way.
But in certain diseases, that defence mechanism malfunctions and rather than providing a short, sharp shock - it produces long-term, chronic pain, seen with some conditions affecting humans such as neuropathies, arthritic pains or migraines.
Researchers at the University of Leeds, in collaboration with colleagues in the US and China, have discovered that, under certain conditions, the molecular sensors that make nerves respond to physical stimuli can be turbo charged - to intensify the electrical signals reaching the brain. The brain interprets those signals as pain.
In animal studies using rat nerve cells, they found that the normal chemical messaging system utilized by the nerves to detect heat and involving calcium ions as 'messengers' was supplemented by what is known as the calcium-activated chlorine channel. It is this combination that amplifies the electrical signal to the brain.
Their research findings are published today (28/4) in the journal Science Signaling.
The research team used a technique called super-resolution microscopy which allowed them to see in exceptional detail the interaction of the molecules involved in nerve signalling.
Nikita Gamper, Professor of Neuroscience in the Faculty of Biological Sciences at Leeds, supervised the research. He said: "Our findings show how environmental threats are detected and then processed by the nervous system.
"And of course, this understanding is also important for us to be able to combat the flip side of the pain sensation - when people begin to experience pain that is no longer protective or beneficial, such as pain from inflammation, cancer and many other conditions.
"These are conditions that damage the quality of life experience by many people."
This pain amplification mechanism happens in the peripheral nervous system which feeds into - but is separate from - the central nervous system, made up of the spinal column and brain. For Professor Gamper, that division opens-up the possibility that drug therapies to reduce chronic pain could be targeted on the peripheral nervous system rather than the brain.
He said: "The painkillers that we currently use act on the central nervous system and brain. Developing painkillers that work on brain function is very hard because the brain is a complex organ and although you might solve one problem, you often get unwanted side effects.
"Opioids are standard analgesics, but they are highly addictive. Therapies based on the peripheral nervous system would potentially have less effect on the brain."
Although the study was conducted on nerve cells from rats and the applicability to the human nervous system is yet to be confirmed, there are reasons to believe that while there is a big difference between the human and rat brains, the peripheral nervous systems bear much closer similarity.
Notes to Editors
For further information, please contact David Lewis in the press office at the University of Leeds: firstname.lastname@example.org.
University of Leeds
The University of Leeds is one of the largest higher education institutions in the UK, with more than 38,000 students from more than 150 different countries, and a member of the Russell Group of research-intensive universities. The University plays a significant role in the Turing, Rosalind Franklin and Royce Institutes.
We are a top ten university for research and impact power in the UK, according to the 2014 Research Excellence Framework, and are in the top 100 of the QS World University Rankings 2020.
The University was awarded a Gold rating by the Government's Teaching Excellence Framework in 2017,?recognising?its 'consistently outstanding' teaching and learning provision. Twenty-six of our academics have been awarded National Teaching Fellowships - more than any other institution in England, Northern Ireland and Wales - reflecting the excellence of our teaching.??http://www.leeds.ac.uk