News Release

Simple test predicts obstructive sleep apnea in patients hospitalized for heart failure

Overnight pulse-oximetry correlates with outpatient polysomnography

Peer-Reviewed Publication

Thomas Jefferson University


image: Jefferson researchers found that for hospitalized heart failure patients, overnight pulse-oximetry correlates with outpatient polysomnography. view more 

Credit: Thomas Jefferson University

PHILADELPHIA, PA - September 8, 2015 -Researchers at Thomas Jefferson University showed that a simple questionnaire, evaluation and pulse-oximetry monitoring can lead to early detection of sleep apnea in patients hospitalized for congestive heart failure (CHF). The results published today in the Journal of American College of Cardiology: Heart Failure.

"Since traditional screenings are not always effective in patients with congestive heart failure, additional tools are needed," said lead author Sunil Sharma, M.D., FAASM, Associate Professor of Pulmonary Medicine in the Sidney Kimmel Medical College at Thomas Jefferson University. "Our team was able to validate a screening strategy that can be instituted during hospitalization and effectively detect sleep disordered breathing among patients with congestive heart failure."

This study adds to a growing body of research suggesting a connection between sleep disordered breathing and heart failure. "While an estimated 70 percent of patients with congestive heart failure have underlying sleep disordered breathing, only a minority, roughly two percent, are diagnosed and treated. Yet early recognition and treatment of this disorder in patients with congestive heart failure has been shown to improve ejection fraction, acute heart failure and may even reduce readmissions and mortality," Dr. Sharma continued.

Consecutive patients admitted for congestive heart failure at Thomas Jefferson University Hospital were screened by respiratory therapists using the STOP-BANG Questionnaire (Snoring, Tiredness during daytime, Observed apnea, high blood Pressure - Body mass index greater than 35, Age greater than 50 years, Neck circumference greater than 40 centimeters and Male gender).

If the patient screened positive, they received a formal sleep consult during their hospital stay and underwent high resolution pulse-oximetry testing, which assessed the patient's oxygen desaturation index (ODI). This low-cost device measures how much oxygen is in a patient's blood. Researchers hypothesized that dips in oxygen levels throughout the night were a sign of obstructive sleep apnea.

Patients with a high ODI were recommended to undergo overnight polysomnography as an outpatient. Of those who followed up with the recommended polysomnography (n=68), 94 percent (n=64) were diagnosed with sleep disordered breathing.

"Patients with congestive heart failure do not always present with traditional symptoms of sleep apnea, like daytime sleepiness and heavy snoring," said Paul J. Mather, M.D., FACC, FACP, Lubert Family Professor of Cardiology in the Sidney Kimmel Medical College at Thomas Jefferson University and Director of the Advanced Heart Failure and Cardiac Transplant Center at the Jefferson Heart Institute. "This study presents cardiologists with a cost-effective clinical pathway to detect sleep disordered breathing while these patients are hospitalized."

"Our team's research showed that overnight pulse-oximetry, a simple low cost device used in the hospital setting, correlates well with the gold-standard polysomnography," said David J. Whellan, M.D., MHS, FACC, FAHA, the James C. Wilson Professor of Medicine in the Sidney Kimmel Medical College at Thomas Jefferson University and senior author on the study. "Future research is need to see if early screening and intervention of sleep disorder breathing, specifically obstructive sleep apnea, can reduce readmissions, morbidity and mortality in patients with congestive heart failure."


Article Reference: Sharma, S., et al. Photoplythesmographic Signal to Screen Sleep-Disordered Breathing in Hospitalized Heart Failure Patients: feasibility of a prospective clinical pathway. JCHF. 2015;3(9):725-731. doi:10.1016/j.jchf.2015.04.015

About Jefferson -- Health is all we do.

Our newly formed organization, Jefferson, encompasses Thomas Jefferson University and Jefferson Health, representing our academic and clinical entities. Together, the people of Jefferson, 19,000 strong, provide the highest-quality, compassionate clinical care for patients, educate the health professionals of tomorrow, and discover new treatments and therapies that will define the future of health care.

Jefferson Health comprises five hospitals, 13 outpatient and urgent care centers, as well as physician practices and everywhere we deliver care throughout the city and suburbs across Philadelphia, Montgomery and Bucks Counties in Pa., and Camden County in New Jersey. Together, these facilities serve more than 78,000 inpatients, 238,000 emergency patients and 1.7 million outpatient visits annually. Thomas Jefferson University Hospital is the largest freestanding academic medical center in Philadelphia. Abington Hospital is the largest community teaching hospital in Montgomery or Bucks counties. Other hospitals include Jefferson Hospital for Neuroscience in Center City Philadelphia; Methodist Hospital in South Philadelphia; and Abington-Lansdale Hospital in Hatfield Township.

Thomas Jefferson University enrolls more than 3,900 future physicians, scientists, nurses and healthcare professionals in the Sidney Kimmel Medical College (SKMC), Jefferson Colleges of Biomedical Sciences, Health Professions, Nursing, Pharmacy, Population Health and is home of the National Cancer Institute (NCI)-designated Sidney Kimmel Cancer Center.

For more information and a complete listing of Jefferson services and locations, visit

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.