image: Mice missing the gene for LTA4 showed heightened airway resistance and remodeling (top right) compared to controls. This effect was mitigated by neutralizing PGP with a compound named RTR (bottom right). This material relates to a paper that appeared in the Aug. 22, 2018, issue of Science Translational Medicine, published by AAAS. The paper, by D.F Patel at Imperial College London in London, UK; and colleagues was titled, "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness." view more
Credit: D.F. Patel <i>et al., Science Translational Medicine</i> (2018)