Anecdotal evidence of food allergies abounds, but just how common are these allergies and intolerances? In a new study, investigators from Brigham and Women's Hospital combed through medical records from more than 2.7 million patients, identifying more than 97,000 with one or more documented food allergy or intolerance. Their findings are published in the Journal of Allergy and Clinical Immunology.
"Recent reports suggest that food allergies are on the rise, with more food-allergy related hospitalizations in the U.S. over the last decade. However, many studies have been based on telephone surveys or have focused on a specific food allergen or allergen group," said Li Zhou, MD, PhD, of the Division of General Medicine Primary Care at BWH. "We recognized that the electronic health record system could offer a treasure trove of information about allergies to better understand which populations may be most affected and just how common food allergies and intolerances are in the U.S."
Some of the team's findings include:
- Food allergy or intolerance were documented for 3.6 percent of the population studied
- Shellfish was the most commonly reported food allergy
- The highest rates of food allergies or intolerance were among females and Asians
The multidisciplinary team, including a medical student, Warren Acker; an allergist, Kimberly Blumenthal, MD, MSc; patient safety experts and informaticians, used food and allergy intolerance data collected at Partners HealthCare between 2000 and 2013, including information from multiple community and specialty hospitals as well as community health centers. The team examined data on culprit foods, reaction(s) to that allergen, date/time of the reaction and more. The research team used the term "food allergies and intolerances" to include any adverse reaction to food (such as hives, anaphylaxis, shortness of breath, wheezing, itching, swelling and more) as well as pseudoallergic reactions, intolerances and even food preferences reported in the health record.
The team looked at a variety of food allergens, finding that almost 13,000 patients had a reported allergy or intolerance to peanut, including more than 7,000 (56.5 percent) who had hives, anaphylaxis, or other potentially IgE-mediated reactions. To better understand the validity of the food allergy data they examined, they looked at specific antibodies produced in response to peanut via the radioallergosorbent test (RAST) or ImmunoCAP test for all patients who reported a peanut allergy.
The overall rate of allergy prevalence that the team found -- 3.6 percent -- is consistent with previous estimates using oral food challenges.
The team also notes that food allergies are quite common but there are fewer than 7,000 allergists/immunologists in the United States; these data suggest the U.S. doesn't have the capacity to evaluate/confirm allergies for all patients who initially test positive (only 1 in 5 patients with a peanut allergy received follow up allergy testing). Food allergies are estimated to cost the U.S. $25 billion annually.
This study was supported by the Agency for Healthcare Research and Quality (grant no. R01HS022728).
Paper cited: Acker WW et al. "Prevalence of food allergies and intolerances documented in electronic health records" Journal of Allergy and Clinical Immunology DOI: 10.1016/j.jaci.2017.04.006
Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare. BWH has more than 4.2 million annual patient visits and nearly 46,000 inpatient stays, is the largest birthing center in Massachusetts and employs nearly 16,000 people. The Brigham's medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in patient care, quality improvement and patient safety initiatives, and its dedication to research, innovation, community engagement and educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Brigham Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, more than 3,000 researchers, including physician-investigators and renowned biomedical scientists and faculty supported by nearly $666 million in funding. For the last 25 years, BWH ranked second in research funding from the National Institutes of Health (NIH) among independent hospitals. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative as well as the TIMI Study Group, one of the premier cardiovascular clinical trials groups. For more information, resources and to follow us on social media, please visit BWH's online newsroom.
Journal of Allergy and Clinical Immunology