May 25, 2016--(BRONX, NY)--Many young adults with abdominal obesity exhibit a readily detectable risk factor for chronic kidney disease (CKD), yet the vast majority don't know they're at risk, according to a study of nationwide health data led by Albert Einstein College of Medicine researchers that was published online today in the journal PLOS ONE.
Einstein researchers analyzed health data on nearly 7,000 non-pregnant young adults. They found that 11 percent of obese Mexican Americans have albuminuria (elevated levels of the protein albumin in the urine), which signals that the kidneys aren't functioning normally and that a person faces a heightened risk for developing CKD. This is four times the prevalence in Hispanics of normal weight. About six percent of whites and blacks with abdominal obesity had elevated levels of the protein.
An estimated one in three Americans is at risk for developing CKD over the course of their lifetime, usually later in adulthood. "Even though chronic kidney disease typically manifests in older people, the disease can start much earlier but often is not recognized early on," said study leader Michal L. Melamed, M.D., associate professor of medicine and of epidemiology & public health at Einstein and attending physician, nephrology at Montefiore Health System. "Because treatment options for CKD are limited, prevention is the best approach for those at risk. A healthier lifestyle in young adults will go a long way toward promoting kidney health later in life."
Previous studies had suggested that abdominal obesity may damage kidney function even before--and perhaps independent of--kidney damage associated with hypertension and diabetes, which are both associated with obesity.
"In this study we wanted to evaluate whether obesity is associated with CKD even in an otherwise healthy young adult population and to identify risk factors that may promote this association," said first author Harini Sarathy, M.D., formerly a resident physician at Jacobi Medical Center, an Einstein clinical affiliate. "We also wanted to see whether race or ethnicity plays a role in linking abdominal obesity with CKD, as studies have suggested."
The Einstein researchers found that excess albumin was present even in the urine of obese individuals with normal blood pressure, glucose levels, and insulin sensitivity, confirming a direct connection between obesity and the albuminuria associated with kidney disease. These findings also suggest that obesity should be considered an independent risk factor for CKD and that doctors should be testing for kidney damage when evaluating obese young adults.
The Einstein researchers analyzed health data on 6,918 non-pregnant adults ages 20 to 40. The data were gathered between 1999 and 2010 by the National Health and Nutrition Examination Survey (NHANES), a program of studies designed to assess the health and nutritional status of adults and children in the United States. The participants self-identified as non-Hispanic white, non-Hispanic black, or Mexican-American. Abdominal obesity (defined as a waist circumference ?102 cm (40 inches) in males and ?88 cm (35 inches) in females) was present in 45 percent of blacks, 40 percent of Mexican-Americans, and 37 percent of whites.
The study also found that among all young adults with albuminuria, fewer than 5 percent had ever been told they have kidney disease. "Clearly, clinicians and public health officials need to do more to identify and treat young people at risk for early progressive kidney disease so they can adopt the behavioral changes to prevent CKD from occurring," said Dr. Melamed.
The paper is titled "Abdominal Obesity, Race and Chronic Kidney Disease in Young Adults: Results from NHANES 1999-2010." Other Einstein authors were Gabriela Henriquez, M.D., Matthew K. Abramowitz, M.D., Tanya Johns, M.D., Amy Skversky, M.D. and Frederick Kaskel, M.D., Ph.D. Additional authors include: Holly Kramer, M.D., M.P.H., of Loyola University Health Sciences Center, Maywood, IL, Sylvia E. Rosas, M.D, of Joslin Diabetes Center and Beth Israel Deaconess Medical Center, Boston, MA, and Juhi Kumar, M.D., M.P.H., of Weill Cornell Medical Center, New York, NY.
The project was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health (R01 DK102952, K23 DK084339, R34 DK102174M, T32 DJ007110, K23DK102925 AND K23 DK099438), and by the American Society of Nephrology.
The authors declare no financial conflict of interest.
About Albert Einstein College of Medicine
About Albert Einstein College of Medicine
Albert Einstein College of Medicine is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2015-2016 academic year, Einstein is home to 731 M.D. students, 193 Ph.D. students, 106 students in the combined M.D./Ph.D. program, and 278 postdoctoral research fellows. The College of Medicine has more than 1,900 full-time faculty members located on the main campus and at its clinical affiliates. In 2015, Einstein received $148 million in awards from the National Institutes of Health (NIH). This includes the funding of major research centers at Einstein in aging, intellectual development disorders, diabetes, cancer, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Through its extensive affiliation network involving Montefiore, Jacobi Medical Center—Einstein’s founding hospital, and three other hospital systems in the Bronx, Brooklyn and on Long Island, Einstein runs one of the largest residency and fellowship training programs in the medical and dental professions in the United States. For more information, please visit www.einstein.yu.edu, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube.