News Release

Miriam Hospital awarded $2.8 million NIH grant to study weight loss, recurring gestational diabetes

Grant and Award Announcement


PROVIDENCE, R.I. - Women who have gestational diabetes (GDM) in one pregnancy are very likely to develop it again on their next pregnancy. Losing weight before the next pregnancy may help reduce this risk. To test this, The Miriam's Weight Control & Diabetes Research Center is partnering with California Polytechnic Institute on a five-year clinical trial. This study will test whether losing weight before pregnancy can help women reduce the chance that they will develop gestational diabetes again.

Research shows that 40 to 73 percent of women with GDM in one pregnancy will have it again in their next pregnancy. Women who have recurrence of GDM have three times the risk of prenatal and perinatal complications and future health problems, including diabetes and cardiovascular disease. Preliminary studies suggest that lowering body weight before pregnancy can reduce the risk of GDM and maternal/fetal complications associated with the condition. This new study will involve more than 250 overweight or obese women with a history of gestational diabetes who plan to have another pregnancy within one to three years. It will examine whether weight loss prior to pregnancy is effective in reducing the risk of recurrence of gestational diabetes, and can improve perinatal outcomes in mothers and children.

"Because women with gestational diabetes in one pregnancy have such a high risk of developing it again in their next pregnancy, we will be working with these women to help them lose weight, become more physically active, and eat a healthy diet. For example, one woman is joining the study because she's concerned about an increased risk of getting diabetes as she gets older and wants to be healthier. We think this program can help her and other women by assisting them with weight loss and improving their health and the health of their baby," said Rena Wing, Ph.D., director of the Weight Control & Diabetes Research Center at The Miriam Hospital and lead investigator for the study test site at The Miriam's Weight Control & Diabetes Research Center.

The program is offered at no cost to women who had gestational diabetes during their last pregnancy and want to lose weight prior to getting pregnant again to improve their own health and that of their next baby. Half of the women will be assigned by chance to an Intensive Intervention program, where women will meet regularly with a counselor to discuss healthy ways to lose weight, increase physical activity, and improve diet before the next pregnancy. The other half of the women will be assigned by chance to a Health Promotion program including two meetings with a counselor to discuss prenatal health and receive education on healthy weight loss, eating, and exercise in preparation for a healthy pregnancy. Both groups will complete measures before and during pregnancy to assess changes in weight, eating, activity, and health; all participants receive payment for completion of study assessments.

Wing added, "The study will directly challenge the current conventional approach to GDM, which focuses on early identification and treatment during pregnancy - and move toward focusing efforts on prevention during the preconception period. Additionally, if effective, this lifestyle change could help prevent severe complications during pregnancy and delivery, providing an immediate, evidence-based therapy for the more than 200,000 U.S. women diagnosed with GDM each year."

Study participants may be eligible if they are:

  • Age 18 or older;
  • Had GDM in last pregnancy; and
  • Are considering to become pregnant within the next three years


For more information on the study or eligibility requirements, please contact The Miriam's Weight Control & Diabetes Research Center at 401-793-8950 or visit

Rena Wing is also a professor of psychiatry and human behavior at The Warren Alpert Medical School of Brown University. Other researchers include Donald Coustan, M.D., director of the Division of Maternal-Fetal Medicine's Prenatal Diabetes Program at Women and Infants Hospital, and a professor of obstetrics and gynecology at The Warren Alpert Medical School of Brown University.

About The Miriam Hospital

The Miriam Hospital is a 247-bed, not-for-profit teaching hospital affiliated with The Warren Alpert Medical School of Brown University. It offers expertise in cardiology, oncology, orthopedics, men's health, and minimally invasive surgery and is home to the state's first Joint Commission-certified Stroke Center and robotic surgery program. The hospital, which received more than $23 million in external research funding last year, is nationally known for its HIV/AIDS and behavioral and preventive medicine research, including weight control, physical activity and smoking cessation. Named 2015-16 best regional hospital in Rhode Island and the Providence metro area by U.S. News & World Report, The Miriam Hospital has been awarded Magnet Recognition for Excellence in Nursing Services five times and is a founding member of the Lifespan health system. Follow us on Facebook, Twitter (@MiriamHospital) and Pinterest.

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