Dogs infected with echinococcosis play a major role in spreading tapeworms across human populations around the world. Now, researchers have developed a "smart collar" which gradually delivers a steady dose of a deworming drug to dogs. The collar successfully reduces the animals' risk of echinococcosis, the team reports in PLOS Neglected Tropical Diseases
Dogs can be infected with either Echinococcus granulosus sensu lato, which causes cystic echinococcosis (CE), or E. multilocularis, which causes alveolar echinococcosis (AE). In China, a national survey showed that CE is endemic in at least 368 counties in northwest China and is co-endemic with AE in 115 of those counties. The role of dogs in transmitting echinococcosis in these areas is significant, and efforts to dose dogs with monthly deworming treatments have been difficult to implement.
In the new work, Xiao-Nong Zhou of the Chinese Center for Disease Control and Prevention and colleagues developed a deworming collar which delivers praziquantel (PZQ), known to be the most effective deworming drug. They designed the collar to be waterproof, anti-collision, cold-proof, and to automatically deliver a regular, quantitative dose of PZQ. 18 smart deworming collars were used for field testing in Seni district of China, and 523 collars were tested in Henzuo city. Dogs for the trial were randomly selected from all registered dogs in each jurisdiction.
In pre-field trials, the 551 collars were 100.0% anti-collision, 99.5% waterproof and 100.0% coldproof, and the automatic PZQ delivery occurred 87.8% of the time, even with the collars being attached to dogs for 12 months in the harsh climates of remote locations on the Tibetan Plateau. The compliance rate of dog owners to attach the collar to their dog was 94.7% in Seni district and 88.8% in Hezuo city. When compared to a control group, dogs in Seni district wearing the smart collar had a 0.182 times risk of a positive Echinococcus antigen test (95%CI 0.049-0.684, P=0.012) and dogs in Hezuo had a 0.336 times risk of a positive antigen test (95% CI 0.178-0.706, P=0.003).
"In order to prevent the transmission of echinococcosis from dogs to humans and livestock completely, we developed a smart Internet of Things (IoT)-based deworming collar which can deliver PZQ baits for dogs automatically and regularly," the researchers say. "Two pilot studies have showed that it is an excellent alternative to existing manual deworming methods, and the difficulties associated with performing deworming in remote areas with scarce resources can be overcome."
Peer-reviewed; Experimental study; Animals
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Citation: Yang S-J, Xiao N, Li J-Z, Feng Y, Ma J-Y, Quzhen G-S, et al. (2021) Smart deworming collar: A novel tool for reducing Echinococcus infection in dogs. PLoS Negl Trop Dis 15(7): e0009443. https://doi.org/10.1371/journal.pntd.0009443
Funding: SJY was continuously supported by the Ganzi Prefecture Workgroup Projects for Echinococcosis Prevention and Control (the serial numbers are 2016-07, 2017-06, 2018-02 and 2019-02 respectively), which was initiated by China CDC to advance the echinococcosis control program in 2015 in the Qinghai-Tibet Plateau. JZL received the award from the NHC Key Laboratory of Echinococcosis Prevention and Control Project (Supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences, 2019PT320004), and JYM received the Key R & D Transformation Projects (Supported by Science and Technology Committee of Qinghai Province, 2020-SF-133). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
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